Multicompartmental Microcylinders

Bhaskar, Srijanani; Hitt, Jonathon; Chang, S. Laura; Lahann, Joerg

doi:10.1002/anie.200806241

Cited by 117 publications

(131 citation statements)

References 35 publications

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“…It is extensively used for the synthesis of non-crosslinked particles via precipitation of polymers from their solutions [243][244][245][246][247], and a limited number of reports describe monomer polymerization [248][249][250], all of which being about nonporous particles. Loscertales et al [248] successfully electrified a coaxial jet composed of two immiscible liquids, the outer one being a commercial photo-polymerizable resin.…”

Section: Other Techniquesmentioning

confidence: 99%

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

Gökmen

Prez

2012

Progress in Polymer Science

446

309

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Section: Other Techniquesmentioning

confidence: 99%

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

Gökmen

Prez

2012

Progress in Polymer Science

446

309

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“…Compartmentalized microcylinders are prepared by a scalable process that involves electrohydrodynamic cojetting (29) of two or more polymer solutions followed by microsectioning (30). Fig.…”

Section: Resultsmentioning

confidence: 99%

Spontaneous shape reconfigurations in multicompartmental microcylinders

Lee

Yoon

Rahmani

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Nature's particles, such as spores, viruses or cells, are adaptive-i.e., they can rapidly alter major phenomenological attributes such as shape, size, or curvature in response to environmental changes. Prominent examples include the hydration-mediated opening of ice plant seeds, actuation of pine cones, or the ingenious snapping mechanism of predatory Venus flytraps that rely on concaveto-convex reconfigurations. In contrast, experimental realization of reconfigurable synthetic microparticles has been extremely challenging and only very few examples have been reported so far. Here, we demonstrate a generic approach towards dynamically reconfigurable microparticles that explores unique anisotropic particle architectures, rather than direct synthesis of sophisticated materials such as shape-memory polymers. Solely enabled by their architecture, multicompartmental microcylinders made of conventional polymers underwent active reconfiguration including shapeshifting, reversible switching, or three-way toggling. Once microcylinders with appropriate multicompartmental architectures were prepared by electrohydrodynamic cojetting, simple exposure to an external stimulus, such as ultrasound or an appropriate solvent, gives rise to interfacial stresses that ultimately cause reversible topographical reconfiguration. The broad versatility of the electrohydrodynamic cojetting process with respect to materials selection and processing suggests strategies for a wide range of dynamically reconfigurable adaptive materials including those with prospective applications for sensors, reprogrammable microactuators, or targeted drug delivery.biomimetic | stimuli-responsive | switchable materials | smart materials | electrojetting

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“…Upon embedding the fibers in a Tissue-Plus matrix and using a cryosectioning instrument (see Experimental Section), it was possible to fabricate cylinders while keeping the two compartments stable. [18] Cylinders are of interest since the shape of particles plays an important role in the modulation of cell uptake, as reported elsewhere. [37] …”

Section: Labeled Fibers and Rodsmentioning

confidence: 93%

“…[16] In this context, poly(lactic-co-glycolic acid) (PLGA) is a biocompatible (FDA approved) [17] and biodegradable polymer, which is widely used to fabricate nanostructures like microgels, nanoparticles, fibers, or rods. [18,19] PLGA can also be loaded with drugs and functional molecules for further surface functionalization. [20,21] Additional complexity has also been imparted to PLGA nanostructures by implementing multicompartmental structures for highly specific applications, such as drug delivery systems containing two different drugs and distinct release profiles.…”

Section: Introductionmentioning

confidence: 99%

Spatial Analysis of Metal–PLGA Hybrid Microstructures Using 3D SERS Imaging

Strozyk

Aberasturi

Gregory

et al. 2017

Adv Funct Materials

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The incorporation of gold nanoparticles in biodegradable polymeric nanostructures with controlled shape and size is of interest toward different applications in nanomedicine. Properties of the polymer such as drug loading and antibody functionalization can be combined with the plasmonic properties of gold nanoparticles, to yield advanced hybrid materials. This study presents a new way to synthesize multicompartmental microgels, fibers, or cylinders, with embedded anisotropic gold nanoparticles. Gold nanoparticles dispersed in an organic solvent can be embedded within the poly(lactic-co-glycolic acid) (PLGA) matrix of polymeric microstructures, when prepared via electrohydrodynamic co-jetting. Prior functionalization of the plasmonic nanoparticles with Raman active molecules allows for imaging of the nanocomposites by surface-enhanced Raman scattering (SERS) microscopy, thereby revealing nanoparticle distribution and photostability. These exceptionally stable hybrid materials, when used in combination with 3D SERS microscopy, offer new opportunities for bioimaging, in particular when long-term monitoring is required.

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Multicompartmental Microcylinders

Cited by 117 publications

References 35 publications

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

Spontaneous shape reconfigurations in multicompartmental microcylinders

Spatial Analysis of Metal–PLGA Hybrid Microstructures Using 3D SERS Imaging

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