“…15 Unfortunately, this method has a high specific absorption rate, low signal-to-noise ratios, and requires specific corrections for the inhomogeneities caused by the sensitivity to the B 1 and B 0 fields 16,17 and its in vivo application remains challenging. Most recently, 3T human 23 Na MRI has been applied to knee, 18 brain 19 and prostate of healthy volunteers in which external 12 or internal (invasive) 20,21 RF resonators were used. While 23 Na resonators such as endorectal (ER) RF coils (invasive) may seem less desirable due to the nature of the procedure or where distortion of the gland is not acceptable, e.g., for biopsy or radiation treatment planning, a significantly higher SNR can be achieved due to the proximity of the coil to the prostate compared with external resonators.…”