In vivo sodium MR imaging of the abdomen at 3T

James, J.R.; Panda, Anshuman; Lin, Chen; Dydak, Ulrike; Dale, Brian M.; Bansal, Navin

doi:10.1007/s00261-015-0428-6

Cited by 10 publications

(3 citation statements)

References 25 publications

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“…The sodium concentration gradient through the medulla of the normal kidney which is the basis of renal function has been reported from sodium MR imaging [277–279]. Body and spine sodium MR imaging is developing and will expand opportunities and applications [280–284] as had been forecast almost 3 decades ago [285]. These studies are just a few of the numerous applications that will continue to evolve as sodium capabilities become available on clinical scanners at 3T and above.…”

Section: 0 Sodium In Human Diseasementioning

confidence: 99%

Quantitative sodium MR imaging: A review of its evolving role in medicine

Thulborn

2018

NeuroImage

142

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Sodium magnetic resonance (MR) imaging in humans has promised metabolic information that can improve medical management in important diseases. This technology has yet to find a role in clinical practice, lagging proton MR imaging by decades. This review covers the literature that demonstrates that this delay is explained by initial challenges of low sensitivity at low magnetic fields and the limited performance of gradients and electronics available in the 1980s. These constraints were removed by the introduction of 3T and now ultrahigh (≥7T) magnetic field scanners with superior gradients and electronics for proton MR imaging. New projection pulse sequence designs have greatly improved sodium acquisition efficiency. The increased field strength has provided the expected increased sensitivity to achieve resolutions acceptable for metabolic interpretation even in small target tissues. Consistency of quantification of the sodium MR image to provide metabolic parametric maps has been demonstrated by several different pulse sequences and calibration procedures. The vital roles of sodium ion in membrane transport and the extracellular matrix will be reviewed to indicate the broad opportunities that now exist for clinical sodium MR imaging. The final challenge is for the technology to be supplied on clinical ≥3T scanners.

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Section: 0 Sodium In Human Diseasementioning

confidence: 99%

Quantitative sodium MR imaging: A review of its evolving role in medicine

Thulborn

2018

NeuroImage

142

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“…10 Furthermore, the data acquisition can be improved with larger and more homogenous transmitter coils and dedicated receiver coil arrays with better coverage and signal-to-noise. 26,27 In addition, improved post-processing might reduce variation. [28][29][30] Another relevant aspect to consider is repetition of this study setup in patients with kidney disease.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the utilization of a Furosemide stress test, which forces a standardized physiological state and a steeper gradient, could be considered 10 . Furthermore, the data acquisition can be improved with larger and more homogenous transmitter coils and dedicated receiver coil arrays with better coverage and signal‐to‐noise 26,27 . In addition, improved post‐processing might reduce variation 28–30 .…”

Section: Discussionmentioning

confidence: 99%

Daytime Variation in Kidney Perfusion, Oxygenation, and Sodium Concentration Assessed by Multiparametric MRI in Healthy Volunteers

Rasmussen,

Bøgh,

Ringgaard

et al. 2023

Magnetic Resonance Imaging

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BackgroundMRI can provide information on kidney structure, perfusion, and oxygenation. Furthermore, it allows for the assessment of kidney sodium concentrations and handling, allowing multiparametric evaluation of kidney physiology. Multiparametric MRI is promising for establishing prognosis and monitoring treatment responses in kidney diseases, but its intraindividual variation during the day is unresolved.PurposeTo investigate the variation in multiparametric MRI measurements from the morning to the evening.Study TypeProspective.PopulationTen healthy volunteers, aged 29 ± 5 without history of kidney disease.Field Strength/Sequence3 T/T1 mapping, blood‐oxygen level dependent imaging, arterial spin labeling perfusion imaging, diffusion weighted imaging, and sodium imaging.AssessmentA multiparametric MRI protocol, yielding T1, R2*, ADC, renal blood flow and renal sodium levels, was acquired in the morning, noon, and evening. The participants were fasting prior to the first examination. Urine biochemical analyses were performed to complement MRI data. The cortex and medulla were analyzed separately in a semi‐automatic fashion, and gradients of total sodium concentration (TSC) and R2* gradients were calculated from outer cortex to inner medulla.Statistical TestAnalyses of variance and mixed‐effects models to estimate differences from time of day. Coefficients of variation to assess variability within and between participants. A P‐value <0.05 was considered statistically significant.ResultsThe coefficients of variation varied from 5% to 18% for proton‐based parametric sequences, while it was 38% for TSC over a day.Data ConclusionMultiparametric MRI is stable over the day. The coefficients of variation over a day were lower for proton multiparametric MRI, but higher for sodium MRI.Evidence Level2Technical EfficacyStage 2

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High Field Sodium MRS/MRI

Kotecha

2017

Magnetic Resonance Imaging in Tissue Engineering

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In vivo sodium MR imaging of the abdomen at 3T

Cited by 10 publications

References 25 publications

Quantitative sodium MR imaging: A review of its evolving role in medicine

Quantitative sodium MR imaging: A review of its evolving role in medicine

Daytime Variation in Kidney Perfusion, Oxygenation, and Sodium Concentration Assessed by Multiparametric MRI in Healthy Volunteers

High Field Sodium MRS/MRI

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