Multichannel quartz crystal microbalance array: Fabrication, evaluation, application in biomarker detection

Tao, Wenyan; Lin, Peng; Ai, Yanqing; Wang, Hairui; Ke, Shanming; Zeng, Xierong

doi:10.1016/j.ab.2015.11.001

Cited by 27 publications

(18 citation statements)

References 31 publications

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“…Many researchers have investigated the detection of acetone using piezoelectric quartz crystal microbalance (QCM) concept. However, most of the studies are irrelevant to this review [107]- [119]. A quartz crystal microbalance sensor utilizing Ag + -ZSM-5 zeolite as an active element was found to be highly sensitive to acetone with detection limit down to 1.2 ppm.…”

Section: Mass Sensitive Breathe Acetone Biosensorsmentioning

confidence: 99%

A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

et al. 2019

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Exhaled breath acetone has been identified as a diabetes biomarker for non-invasive diagnosis. Its detection using biosensors features has many advantages over the conventional means. This paper reviews the recent literature on the detection of exhaled breath acetone and acetone vapor of diabetic interest. The biosensors have been classified based on their transduction methods. The performance characteristics of the biosensors have been explored for comparison. The future trends are also highlighted.

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Section: Mass Sensitive Breathe Acetone Biosensorsmentioning

confidence: 99%

A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

et al. 2019

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“…Through the years, several MQCMs have been developed for advanced sensing applications, including electronic nose, electronic tongue, and biosensor arrays [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. The use of MQCM technology leads to relevant benefits including multi-analysis capabilities, lower cost per sensor unit, less sample/reagent consumption, faster sensing response, and shorter detection assay time.…”

Section: Introductionmentioning

confidence: 99%

Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications

Fernandez¹,

Bou-Belda²,

García³

et al. 2017

Sensors

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Acoustic wave resonators have become suitable devices for a broad range of sensing applications due to their sensitivity, low cost, and integration capability, which are all factors that meet the requirements for the resonators to be used as sensing elements for portable point of care (PoC) platforms. In this work, the design, characterization, and validation of a 150 MHz high fundamental frequency quartz crystal microbalance (HFF-QCM) sensor for bio-sensing applications are introduced. Finite element method (FEM) simulations of the proposed design are in good agreement with the electrical characterization of the manufactured resonators. The sensor is also validated for bio-sensing applications. For this purpose, a specific sensor cell was designed and manufactured that addresses the critical requirements associated with this type of sensor and application. Due to the small sensing area and the sensor’s fragility, these requirements include a low-volume flow chamber in the nanoliter range, and a system approach that provides the appropriate pressure control for assuring liquid confinement while maintaining the integrity of the sensor with a good base line stability and easy sensor replacement. The sensor characteristics make it suitable for consideration as the elemental part of a sensor matrix in a multichannel platform for point of care applications.

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“…A metallophthalocyanine with silica hybrid film and a metal oxide with MWCNT nanocomposite were applied on two of the three sensing areas while the third was left blank as reference. The array was successfully used for the selective detection of acetone and nitric oxide (including mixtures) as volatile biomarkers for potential application in early asthma and diabetes diagnosis [122].…”

Section: Qcm Multi-sensor Arraysmentioning

confidence: 99%

Bulk and Surface Acoustic Wave Sensor Arrays for Multi-Analyte Detection: A Review

Länge

2019

Sensors

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Bulk acoustic wave (BAW) and surface acoustic wave (SAW) sensor devices have successfully been used in a wide variety of gas sensing, liquid sensing, and biosensing applications. Devices include BAW sensors using thickness shear modes and SAW sensors using Rayleigh waves or horizontally polarized shear waves (HPSWs). Analyte specificity and selectivity of the sensors are determined by the sensor coatings. If a group of analytes is to be detected or if only selective coatings (i.e., coatings responding to more than one analyte) are available, the use of multi-sensor arrays is advantageous, as the evaluation of the resulting signal patterns allows qualitative and quantitative characterization of the sample. Virtual sensor arrays utilize only one sensor but combine it with enhanced signal evaluation methods or preceding sample separation, which results in similar results as obtained with multi-sensor arrays. Both array types have shown to be promising with regard to system integration and low costs. This review discusses principles and design considerations for acoustic multi-sensor and virtual sensor arrays and outlines the use of these arrays in multi-analyte detection applications, focusing mainly on developments of the past decade.

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Multichannel quartz crystal microbalance array: Fabrication, evaluation, application in biomarker detection

Cited by 27 publications

References 31 publications

A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

Design and Validation of a 150 MHz HFFQCM Sensor for Bio-Sensing Applications

Bulk and Surface Acoustic Wave Sensor Arrays for Multi-Analyte Detection: A Review

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