A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

Usman, Fahad; Dennis, John Ojur; Ahmed, A. Y.; Mériaudeau, Fabrice; Ayodele, Olumide Bolarinwa; Rabih, Almur Abdelkreem Saeed

doi:10.1109/access.2018.2887066

Cited by 51 publications

(38 citation statements)

References 115 publications

(141 reference statements)

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“…The selectivity of the PANI/chitosan-and the ternary composite-based SPR biosensors to acetone vapour was also investigated by examining the sensor response (SPR shift) to the common interfering vapours such as ethanol, methanol, and ammonia [79,80]. Figure 8(d) shows the selectivity of the two sensing layers to 10 ppm concentrations of acetone, ethanol, methanol, and ammonia vapours with their refractive index values estimated based on Arago-Biot mixing formula (equation 17).…”

Section: Journal Of Sensorsmentioning

confidence: 99%

Enhanced Sensitivity of Surface Plasmon Resonance Biosensor Functionalized with Doped Polyaniline Composites for the Detection of Low-Concentration Acetone Vapour

et al. 2019

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PANI/chitosan composite and a ternary composite comprising of PANI, chitosan, and reduced graphene oxide have been successfully synthesised and characterised using FTIR and UV-VIS spectroscopy. Optical constants of the composites were extracted from the UV-VIS spectra. The extracted parameters were applied in the simulation of a surface plasmon resonance (SPR) biosensor functionalised with PANI/chitosan and ternary composites. The aim was to explore the applicability of the composite-based SPR sensor in the detection of low-concentration acetone vapour within the range of 1.8 ppm–5.0 ppm for diabetes monitoring and screening. The functionalization of the SPR sensor with the PANI/chitosan and the ternary composites shows promising application of the sensor in the detection of acetone vapour at a low concentration down to less than 0.5 ppm. The maximum sensitivity values of about 60 and 180 degree/refractive index change were observed for PANI/chitosan and ternary composite sensing layers, respectively, in comparison with the bare gold-based SPR which shows no response up to 10 ppm concentration of acetone vapour in air. In addition, the two sensing layers show good selectivity to acetone vapour compared to ethanol, methanol, and ammonia. The response in the case of ternary composite shows better linearity with a correlation coefficient of 1.0 compared to PANI/chitosan- and gold-based SPR layers with 0.9999 and 0.9997, respectively.

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Section: Journal Of Sensorsmentioning

confidence: 99%

Enhanced Sensitivity of Surface Plasmon Resonance Biosensor Functionalized with Doped Polyaniline Composites for the Detection of Low-Concentration Acetone Vapour

et al. 2019

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“…Importantly, diabetes patients critically need 24/7 management [55]. Monitoring the blood glucose (BG) level using wearable sensors has a vital role in diabetes treatment revolution nowadays [56][57][58]. Table 2 shows wearable sensing technologies [59][60][61].…”

Section: Introductionmentioning

confidence: 99%

A review of wearable sensors based monitoring with daily physical activity to manage type 2 diabetes

AlShorman

Alshorman²,

Alkahtani

2021

IJECE

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Globally, the aging and the lifestyle lead to rabidly increment of the number of type two diabetes (T2D) patients. Critically, T2D considers as one of the most challenging healthcare issue. Importantly, physical activity (PA) plays a vital role of improving glycemic control T2D. However, daily monitoring of T2D using wearable devices/ sensors have a crucial role to monitor glucose levels in the blood. Nowadays, daily physical activity (PA) and exercises have been used to manage T2D. The main contribution of the proposed study is to review the literature about managing and monitoring T2D with daily PA through wearable devices and sensors. Finally, challenges and future trends are also highlighted.

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“…Diabetes is a disease that occurs due to improper regulation of human blood sugar [ 1 ]. Genetics and environmental factors such as population growth, ageing, urbanization, obesity, and physical inactivity are the most common causes of diabetes [ 2 , 3 ]. Some of the complications of diabetes include damage to blood vessels which can lead to heart attack and stroke, and problems with the kidneys, eyes, feet and nerves [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…These necessitate the need for a real-time and non-invasive means of diagnosing diabetes. Exhaled breath acetone has been identified as a good biomarker for the non-invasive diagnosis of diabetes [ 2 ]. It was stated that acetone concentration in the human body is generally very low (0.1 ppm–0.8 ppm), while it might be high in the case of metabolism disorders, including diabetes mellitus (DM) (1.8 ppm–5.0 ppm) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The conventional means of acetone vapour detection such as gas chromatography—mass spectrometry (GC-MS) and selected ion flow tube mass spectrometry (SIFT-MS) are capable of detecting traces of acetone vapour with good sensitivity and selectivity. However, these methods are expensive and rely on sophisticated instrumentation, complicated sample collection methods, and are found only at advanced medical institutions [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Acetone Vapour Sensing Properties of a Ternary Composite of Doped Polyaniline, Reduced Graphene Oxide and Chitosan Using Surface Plasmon Resonance Biosensor

et al. 2020

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This work reports the use of a ternary composite that integrates p-Toluene sulfonic acid doped polyaniline (PANI), chitosan, and reduced graphene oxide (RGO) as the active sensing layer of a surface plasmon resonance (SPR) sensor. The SPR sensor is intended for application in the non-invasive monitoring and screening of diabetes through the detection of low concentrations of acetone vapour of less than or equal to 5 ppm, which falls within the range of breath acetone concentration in diabetic patients. The ternary composite film was spin-coated on a 50-nm-thick gold layer at 6000 rpm for 30 s. The structure, morphology and chemical composition of the ternary composite samples were characterized by FTIR, UV-VIS, FESEM, EDX, AFM, XPS, and TGA and the response to acetone vapour at different concentrations in the range of 0.5 ppm to 5 ppm was measured at room temperature using SPR technique. The ternary composite-based SPR sensor showed good sensitivity and linearity towards acetone vapour in the range considered. It was determined that the sensor could detect acetone vapour down to 0.88 ppb with a sensitivity of 0.69 degree/ppm with a linearity correlation coefficient of 0.997 in the average SPR angular shift as a function of the acetone vapour concentration in air. The selectivity, repeatability, reversibility, and stability of the sensor were also studied. The acetone response was 87%, 94%, and 99% higher compared to common interfering volatile organic compounds such as propanol, methanol, and ethanol, respectively. The attained lowest detection limit (LOD) of 0.88 ppb confirms the potential for the utilisation of the sensor in the non-invasive monitoring and screening of diabetes.

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A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

Cited by 51 publications

References 115 publications

Enhanced Sensitivity of Surface Plasmon Resonance Biosensor Functionalized with Doped Polyaniline Composites for the Detection of Low-Concentration Acetone Vapour

Enhanced Sensitivity of Surface Plasmon Resonance Biosensor Functionalized with Doped Polyaniline Composites for the Detection of Low-Concentration Acetone Vapour

A review of wearable sensors based monitoring with daily physical activity to manage type 2 diabetes

Investigation of Acetone Vapour Sensing Properties of a Ternary Composite of Doped Polyaniline, Reduced Graphene Oxide and Chitosan Using Surface Plasmon Resonance Biosensor

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