Multicentric EBV-associated smooth muscle tumour with involvement of the pituitary gland

Lau, Stephanie; Zhu, Jasmine; Tan, A; Grossmann, Mathis; Zajac, Jeffrey D; Clark, Jonathan

doi:10.1016/j.pathol.2021.08.012

Cited by 1 publication

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References 9 publications

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“…EBV is associated with lymphoma, Hodgkin's disease, nasopharyngeal carcinoma, gastric adenocarcinoma, and lymphoepithelioma‐like carcinomas. 119 , 120 , 121 , 122 EBV associated with smooth muscle tumor (SMT) of the larynx has been reported. 123 Whaley et al 123 identified 12 cases of EBV‐associated laryngeal SMT.…”

Section: Discussion/literature Reviewmentioning

confidence: 99%

Epstein–Barr virus‐associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature

et al. 2022

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We investigated the clinical features, treatment, and prognosis of laryngeal leiomyosarcoma (LLMS) and Epstein-Barr virus-associated (EBV-associated) LMS. We report a case of EBV-associated LLMS in an adult patient with HIV infection. We also conducted a review of the English-language literature on LLMS and EBV-associated leiomyosarcoma. To the best of our knowledge, 62 cases of LLMS and EBV-associated leiomyosarcoma have been reported to date. Of patients with LLS, 18.9% had distant metastases and 17.0% had local recurrence. The overall 5-year survival rate was 64.0%. Distant metastases affected the survival of patients with LLMS (p = 0.04). EBV-positive patients had a low survival rate (p = 0.01). Among patients with EBV-associated LMS, 8.2% had distant metastases and recurrence and the overall 5-year survival rate was 50.0%. EBV-associated LLMS is rare. The EBV infection might be a poor prognostic factor of LLMS.

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