Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. EAGLE Study report no. 1

Feltgen, Nicolas; Neubauer, Aljoscha S.; Jurklies, Bernhard; Schmoor, Claudia; Schmidt, Dieter; Wanke, J.; Maier-Lenz, H.; Schumacher, Martin

doi:10.1007/s00417-005-0140-2

Cited by 107 publications

(62 citation statements)

References 33 publications

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“…9 This is usually set at 80 years, 4,32-34 though 75 35 and 85 years 2,36 have also been used. In a pooled analysis of 101 patients from 4 prospective studies, patients Ն80 years had a lower likelihood of favorable outcome (OR, 0.34; 95% CI, 0.1-1.1; P ϭ .07) and higher mortality rates (OR, 3.62; 95% CI, 1.15-11.36; P ϭ .027) following IA thrombolysis for acute stroke after adjusting for recanalization.…”

Section: Predictors Of Futile Recanalizationmentioning

confidence: 99%

Occurrence and Predictors of Futile Recanalization following Endovascular Treatment among Patients with Acute Ischemic Stroke: A Multicenter Study

Hussein¹,

Georgiadis²,

Vázquez³

et al. 2010

AJNR Am J Neuroradiol

165

159

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Section: Predictors Of Futile Recanalizationmentioning

confidence: 99%

Occurrence and Predictors of Futile Recanalization following Endovascular Treatment among Patients with Acute Ischemic Stroke: A Multicenter Study

Hussein¹,

Georgiadis²,

Vázquez³

et al. 2010

AJNR Am J Neuroradiol

165

159

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“…An ongoing multicentre study is testing efficacy. 30 Localized application of hypothermia to the affected eye is a simple technique that decreased injury in animal studies after ischaemia, 29 and it is probably reasonable to institute in humans because of minimal risk.…”

Section: Prognosis and Treatmentmentioning

confidence: 99%

Perioperative visual loss: what do we know, what can we do?

Roth¹

2009

British Journal of Anaesthesia

254

116

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Perioperative visual loss (POVL), a rare, but devastating complication, can follow non-ocular surgery. Highest rates of visual loss are with cardiac and spine surgery. The main causes of visual loss after non-ocular surgery are retinal vascular occlusion and ischaemic optic neuropathy. This review updates readers on the incidence, suspected risk factors, diagnosis, and treatment of POVL due to these conditions. Br J Anaesth 2009; 103 (Suppl. 1): i31-i40Keywords: complications, neurological; complications, neuropathy; eye, intraocular pressure; eye, pupil; surgery, spinal Visual loss after anaesthesia and surgery is a rare, unexpected, and devastating complication. Clinicians have suspected that incidence is increasing, particularly with spinal fusion surgery; however, recent data suggest that this may not be the case. This review will update readers on the incidence, suspected risk factors, diagnosis, and treatment of perioperative visual loss (POVL), in the setting of non-ocular surgery. The causes of POVL are primarily retinal vascular occlusion (RVO) and ischaemic optic neuropathy (ION). The relevant anatomy of the ocular circulation has been reviewed elsewhere and is summarized in Figure 1. 80 Other sources are glycine toxicity during transurethral resection of the prostate, acute angle closure glaucoma, cortical blindness, and expansion of an intraocular sulphur hexafluoride vitrectomy bubble by administration of nitrous oxide. As these are less common, the reader is referred for details to a recent more inclusive review. 80

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“…5 There has been recent interest in the use of tissue plasminogen activator (tPA) with two recent randomized controlled trials on the treatment of acute CRAO. 6,7 The aim of this review article is to provide a comprehensive overview of the epidemiology, risk factors, and clinical presentation of CRAO, but more importantly to review the evidence for treatment.…”

Section: Introductionmentioning

confidence: 99%

A review of central retinal artery occlusion: clinical presentation and management

Varma

Cugati

Lee

et al. 2013

Eye

325

298

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Central retinal artery occlusion (CRAO) is an ophthalmic emergency and the ocular analogue of cerebral stroke. Best evidence reflects that over three-quarters of patients suffer profound acute visual loss with a visual acuity of 20/400 or worse. This results in a reduced functional capacity and quality of life. There is also an increased risk of subsequent cerebral stroke and ischaemic heart disease. There are no current guideline-endorsed therapies, although the use of tissue plasminogen activator (tPA) has been investigated in two randomized controlled trials. This review will describe the pathophysiology, epidemiology, and clinical features of CRAO, and discuss current and future treatments, including the use of tPA in further clinical trials.

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Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. EAGLE Study report no. 1

Cited by 107 publications

References 33 publications

Occurrence and Predictors of Futile Recanalization following Endovascular Treatment among Patients with Acute Ischemic Stroke: A Multicenter Study

Occurrence and Predictors of Futile Recanalization following Endovascular Treatment among Patients with Acute Ischemic Stroke: A Multicenter Study

Perioperative visual loss: what do we know, what can we do?

A review of central retinal artery occlusion: clinical presentation and management

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