2010
DOI: 10.3174/ajnr.a2006
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Abstract: BACKGROUND AND PURPOSE:Although recanalization is the goal of thrombolysis, it is well recognized that it fails to improve outcome of acute stroke in a subset of patients. Our aim was to assess the rate of and factors associated with "futile recanalization," defined by absence of clinical benefit from recanalization, following endovascular treatment of acute ischemic stroke.

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Cited by 161 publications
(163 citation statements)
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“…Still, many trials describe dissociation between high rates of successful reperfusion and relatively low rates of independent functional outcome [4][5][6] . One potential explanation for such dissociation is the heterogeneity in defining the procedural success of mechanical stroke therapy.…”
Section: Introductionmentioning
confidence: 99%
“…Still, many trials describe dissociation between high rates of successful reperfusion and relatively low rates of independent functional outcome [4][5][6] . One potential explanation for such dissociation is the heterogeneity in defining the procedural success of mechanical stroke therapy.…”
Section: Introductionmentioning
confidence: 99%
“…4 Although recanalization is a beneficial and necessary target in the treatment of acute stroke, it is not always associated with improved clinical outcome. [6][7][8] In the PROACT II and IMS II trials, 26% and 55% of patients with recanalization did not show clinical improvement. 2 Furthermore, both IV and IA therapies for acute stroke are associated with risks that may influence the decision to treat if a good outcome is considered unlikely.…”
mentioning
confidence: 99%
“…Clinical prognostic factors such as older age, higherNIHSS score, and longer delay between symptom onset and treatment, proposed as markers of futile recanalization [1,2], are not sufficiently discriminatory for treatment decisions.…”
Section: Discussionmentioning
confidence: 99%