Multiaxial mechanical properties and constitutive modeling of human adipose tissue: A basis for preoperative simulations in plastic and reconstructive surgery

Sommer, Gerhard; Eder, Maximilian; Kovâcs, László; Pathak, Heramb; Bonitz, Lars; Mueller, Christoph; Regitnig, Peter; Holzapfel, Gerhard

doi:10.1016/j.actbio.2013.06.011

Cited by 92 publications

(71 citation statements)

References 25 publications

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“…Adipose consists of 90-99% triglyceride, with the remaining tissue containing 5-30% water and 2-3% proteins (Albright & Stern, 1998). The tissue is a loose association of lipid filled cells called white adipocytes (80μm diameter approximately) held in two extracellular networks of collagen fibres penetrated by fibroblasts, neural and vascular cells, and multipotent progenitor cells (Geerligs et al, 2008;Young & Christman, 2012;Sommer et al, 2013). The smaller network is a reinforcement basement membrane, comprised of collagen fibres, which acts as the walls of a closed cell foam with the adipocyte forming the cavity.…”

Section: Subcutaneous Adipose Tissuementioning

confidence: 99%

“…Adipose, as with most biological tissues, exhibits heterogeneous, rate-dependent, viscoelastic behaviour and experiences large non-linear deformations (Holzapfel, 2004;Sapozhnikov & Ignatova, 2013). It is suggested that adipose is approximately isotropic in structure and due to the large liquid content is almost incompressible (Samani et al, 2003;Comley & Fleck, 2010), though a recent study by Sommer et al (2013) observed some anisotropy in specimens.…”

Section: Subcutaneous Adipose Tissuementioning

confidence: 99%

“…Much of current research only presents linear material parameters (e.g. Young's modulus) at quasi-static strain rates whilst it is widely documented that the tissue exhibits a non-linear response and significant rate dependence (Comley & Fleck, 2012;Samani & Plewes, 2004;Alkhouli et al, 2013;Sommer et al, 2013).…”

Section: Subcutaneous Adipose Tissuementioning

confidence: 99%

See 2 more Smart Citations

The evaluation of new multi-material human soft tissue simulants for sports impact surrogates

Payne

Mitchell

Bibb

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Subcutaneous Adipose Tissuementioning

confidence: 99%

Section: Subcutaneous Adipose Tissuementioning

confidence: 99%

See 1 more Smart Citation

The evaluation of new multi-material human soft tissue simulants for sports impact surrogates

Payne

Mitchell

Bibb

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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“…There is little data in literature, but in general, the ultimate strength of biological tissues and organs of the abdomen is around 10 kPa and is reached for a deformation of about 20% (Sommer et al, 2013). Uniaxial and biaxial simulations show that for a stress about 100 kPa (ten times the maximum stress admissible by human organs), the membrane is still fully elastic.…”

Section: Discussionmentioning

confidence: 99%

Mechanical properties of a nanoporous membrane used in implantable medical devices. Correlation between experimental characterization and 2D numerical simulation

Cristofari

Piotrowski

Pesci

2017

Journal of the Mechanical Behavior of Biomedical Materials

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is an open access repository that collects the work of Arts et Métiers ParisTech researchers and makes it freely available over the web where possible. A B S T R A C TNanoporous membranes are used for the elaboration of implantable medical devices. In order to guaranty their integrity after implantation in a patient body, it is necessary to characterize the microstructure and the mechanical behavior of such membranes. They present randomly distributed pores around 1 µm in diameter at the surface. X-ray nanotomography permits to get the geometry of the pores through the thickness with a reduction of the diameter in the core. A multiscale study is done to characterize the membranes: macroscopic tensile tests permit to get the behavior law of the non porous material and in situ tensile tests are carried on in a Scanning Electron Microscope in order to observe the evolution of pores and cracks during loading. A 2D Finite Element Model is also developed in parallel. The confrontation between experiments and numerical simulations permit to validate the accuracy of the model. The latter is then used to simulate several types of loadings considering various pore distributions and sizes.

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“…Although nonlinear isotropic material models such as the Ogden, Mooney-Rivlin and Neo-Hookean ones have been used to describe the mechanical response of skin [9], [10], [19], more adequate anisotropic structural formulations, i.e. accounting for the real collagenous structure of soft tissues, have recently been developed [7], [15], [16], [20], [21], which more coherently represent their mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

A Constitutive Framework for Human Dermis Mechanical Modelling

Aldieri¹,

Terzini²,

Bignardi³

et al. 2017

Materials and Contact Characterisation VIII

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Finite element models, in conjunction with adequate constitutive relations of the materials involved, have proved to be crucial in many medical applications, such as in surgical planning. Nevertheless, a thorough numerical analysis of dermis' mechanical response is a challenging research area because of dermis' highly anisotropic and nonlinear behaviour. The aim of this work has been to assess the performance of two orthotropic and one isotropic hyper-elastic constitutive laws, providing an experimental-computational framework for the definition of reliable constitutive models of dermis tissue. Experimental, equi-biaxial stress-strain data obtained on human reticular dermis specimens have been exploited in order to extract, through a stochastic optimization procedure, constitutive parameters of three widely used constitutive laws: the Ogden, Holzapfel and Gasser-Ogden-Holzapfel (GOH) models. A set of specimen specific parameters and a set of best matching parameters, determined by simultaneously fitting all experimental stress-strain curves, have been obtained. The goodness of the selected laws has been assessed by means of FEM simulations performed in Abaqus (Simulia, Dessault Systèmes Inc.) which reproduce the actual specimen boundary conditions and geometry, rebuilt through an image segmentation process implemented in MATLAB (The MathWorks, Inc.). Models have been validated comparing experimental and numerical outcomes related to reference points on the specimen surface. In the preliminary fitting phase, Normalized Root Mean Square Error values were above 0.9 for the specimen-specific and above 0.54 for the best matching models. The comparison between numerical and experimental outcomes has highlighted the inadequacy of the isotropic constitutive law in reproducing the dermis behaviour, particularly at higher stretch levels. Errors obtained in the horizontal loading direction are lower than 40% for Holzapfel and GOH models, while the Ogden model reaches the 80%. Lower and more uniform errors occur in the orthogonal direction, which settles below 30% for the orthotropic laws, while it increases up to 40% in the isotropic case.

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Multiaxial mechanical properties and constitutive modeling of human adipose tissue: A basis for preoperative simulations in plastic and reconstructive surgery

Cited by 92 publications

References 25 publications

The evaluation of new multi-material human soft tissue simulants for sports impact surrogates

The evaluation of new multi-material human soft tissue simulants for sports impact surrogates

Mechanical properties of a nanoporous membrane used in implantable medical devices. Correlation between experimental characterization and 2D numerical simulation

A Constitutive Framework for Human Dermis Mechanical Modelling

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