Multi-walled carbon nanotubes (MWCNT): Induction of DNA damage in plant and mammalian cells

Ghosh, Manosij; Chakraborty, Anirban; Bandyopadhyay, Maumita; Mukherjee, Anita

doi:10.1016/j.jhazmat.2011.09.090

Cited by 108 publications

(53 citation statements)

References 46 publications

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“…On the contrary, the presence of MWNT during repair processes probably entail disorders in radioinduced DNA damage repair, cell division, and other vital functions resulting in the cells death and lack of attached cells. These suggestions are confirmed by Ghosh and Patlolla, who observed negative influence of MWNT on spindle and cell viability [14,15].…”

Section: Studies Of Genotoxicity and Influence On Dna Damage Repairsupporting

confidence: 62%

Applications of Comet Assay for the Evaluation of Genotoxicity and DNA Repair Efficiency in Nanomaterials Research

et al. 2018

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The single cell gel electrophoresis method, known as comet assay, is a rapid and sensitive technique for testing novel chemicals and nanoparticles for genotoxicity, monitoring environmental contamination with genotoxins and human biomonitoring. In our studies we check the applicability of this method for the evaluation of biocompatibility of modified (MWNF) and non-modified multi-walled carbon nanotubes (MWNT) as well as potential genotoxicity of mercury(II) nitrate. The obtained results enabled us to conclude that the presence of Hg(NO3q2 (p 0.001) and MWNT (p 0.04) cause a significantly higher level of DNA damage in comparison to functionalised nanomaterials MWNF. It was implied that for the three investigated agents only mercury significantly enhanced genotoxic effect of X-ray exposure (p 0.001) and inhibition of radio-induced DNA damage repair. On the contrary, the presence of MWNF have no influence on cellular repair efficiencies, while incubation with MWNT causes apoptosis and consequently results in lack of attached cells. In conclusion, our results confirmed the genotoxicity of mercury and non-modified carbon nanotubes as well as the biocompatibility of modified nanotubes. Additionally, we proved the usefulness of comet method for the evaluation of genotoxicity and DNA repair under the influence of different compounds and nanomaterials.

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Section: Studies Of Genotoxicity and Influence On Dna Damage Repairsupporting

confidence: 62%

Applications of Comet Assay for the Evaluation of Genotoxicity and DNA Repair Efficiency in Nanomaterials Research

et al. 2018

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“…Accordingly, the potential toxicity of nanoparticles on plants has not yet been widely investigated, and the reported results are frequently descriptive and contradictory with very limited information on the underlying modes of action [117]. Physiological processes potentially affected by interactions with nanomaterials comprise alterations of gene expression [118,119], DNA damage [120,121] and increased formation of ROS [122,123]. A high variability of responses can be observed between different plant species [124,125], various stages of plant ontogenesis [126] and different varieties [127,128].…”

Section: Impact Of Carbon-based Nanomaterials On Plantsmentioning

confidence: 99%

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

Zaytseva

Neumann

2016

Chem. Biol. Technol. Agric.

378

166

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During the relatively short time since the discovery of fullerenes in 1985, carbon nanotubes in 1991, and graphene in 2004, the unique properties of carbon-based nanomaterials have attracted great interest, which has promoted the development of methods for large-scale industrial production. The continuously increasing commercial use of engineered carbon-based nanomaterials includes technical, medical, environmental and agricultural applications. Regardless of the application field, this is also associated with an increasing trend of intentional or unintended release of carbon nanomaterials into the environment, where the effect on living organisms is still difficult to predict. This review describes the different types of carbon-based nanomaterials, major production techniques and important trends for agricultural and environmental applications. The current status of research regarding the impact of carbon nanomaterials on plant growth and development is summarized, also addressing the currently most relevant knowledge gaps.

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“…Over the past decade, a number of studies have investigated MWCNT-induced toxicity and potential carcinogenesis in mammalian systems, which has been elegantly reviewed by Toyokuni [6]. However, only limited information regarding the toxicity of MWCNT is available in the plant system [7][8][9][10][11][12][13]. With few exceptions, most of these studies have addressed the effect on physiological parameters and germination rates.…”

mentioning

confidence: 99%

MWCNT uptake in Allium cepa root cells induces cytotoxic and genotoxic responses and results in DNA hyper-methylation

Ghosh

Bhadra

Adegoke

et al. 2015

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

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147

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Multi-walled carbon nanotubes (MWCNT): Induction of DNA damage in plant and mammalian cells

Cited by 108 publications

References 46 publications

Applications of Comet Assay for the Evaluation of Genotoxicity and DNA Repair Efficiency in Nanomaterials Research

Applications of Comet Assay for the Evaluation of Genotoxicity and DNA Repair Efficiency in Nanomaterials Research

Carbon nanomaterials: production, impact on plant development, agricultural and environmental applications

MWCNT uptake in Allium cepa root cells induces cytotoxic and genotoxic responses and results in DNA hyper-methylation

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