“…Thus, it can be speculated that, in the mouse test battery employed in this study, dimebon affects a number of receptors and may act as a multi-target drug, i.e. the concentrations used in this study, which correspond to sub-threshold levels for receptor activation via a mono-target mechanism, are only able to evoke physiological effects by synergistic activation of several neurotransmitter systems (Youdim and Buccafusco, 2005;Cavalli et al, 2008). The memory-enhancing effects of dimebon may indicate simultaneous activity toward AMPA, NMDA, dopamine and serotonin receptors, all of which have been involved in inhibitory and appetitive hippocampus-dependent learning (Ungerer et al, 1998;Orsetti et al, 2001;Rogawski and Wenk, 2003;LaLumiere et al, 2003;Lynch and Gall, 2006;Balschun et al, 2006;Da Silva Costa et al, 2009;Benchenane et al, 2010).…”