Multi-Stimuli Responsive Sequence Defined Multi-Arm Star Diblock Copolymers for Controlled Drug Release

Dolui, Subrata; Sahu, Bhanendra; Mohammad, Sk Arif; Banerjee, Sanjib

doi:10.1021/jacsau.3c00339

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Star-shaped graft copolymers, distinguished by their inherent three-dimensional structures and adjustable functional group densities, manifest distinct physical properties when contrasted with traditional linear copolymers. 1–3 These polymers hold promise across a spectrum of applications, spanning drug delivery, 4–6 solid-state electrolytes, 7 adhesives, 8,9 nanofillers, 10 and thermoplastic elastomers. 11 Nevertheless, the current state of star-shaped graft copolymers is characterised by two significant challenges.…”

Section: Introductionmentioning

confidence: 99%

One-pot strategy to access dynamic dual network from lignin-initiated star polymers by side reaction and transesterification

Yan,

Xue,

Zhang

et al. 2024

Polym. Chem.

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Section: Introductionmentioning

confidence: 99%

One-pot strategy to access dynamic dual network from lignin-initiated star polymers by side reaction and transesterification

Yan,

Xue,

Zhang

et al. 2024

Polym. Chem.

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Stimuli-Responsive Polymeric Nanocarriers Accelerate On-Demand Drug Release to Combat Glioblastoma

Ismail,

Wang,

et al. 2024

Biomacromolecules

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Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a poor prognosis and limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great promise for improving the treatment modalities of GBM. At the beginning of the review, we highlighted the stimuli-active polymeric nanocarriers carrying therapies that potentially boost anti-GBM responses by employing endogenous (pH, redox, hypoxia, enzyme) or exogenous stimuli (light, ultrasonic, magnetic, temperature, radiation) as triggers for controlled drug release mainly via hydrophobic/hydrophilic transition, degradability, ionizability, etc. Modifying these nanocarriers with target ligands further enhanced their capacity to traverse the blood–brain barrier (BBB) and preferentially accumulate in glioma cells. These unique features potentially lead to more effective brain cancer treatment with minimal adverse reactions and superior therapeutic outcomes. Finally, the review summarizes the existing difficulties and future prospects in stimuli-responsive nanocarriers for treating GBM. Overall, this review offers theoretical guidelines for developing intelligent and versatile stimuli-responsive nanocarriers to facilitate precise drug delivery and treatment of GBM in clinical settings.

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Preparation of Porphyrin-Based Unimolecular Micelles for Synergistic Photodynamic Therapy and Radiotherapy

Song,

Ren,

et al. 2024

ACS Appl. Polym. Mater.

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Polymeric carriers have been widely used in biomedical fields because of their strong structural tunability and biocompatibility, which often proximately determine the in vivo behavior of the drug and are crucial in practical application. In this work, porphyrin-based unimolecular micelles with an average diameter less than 20 nm are developed by light-mediated bromine–iodine transformation reversible-deactivation radical polymerization (BIT-RDRP) for synergistic photodynamic therapy (PDT) and radiotherapy (RT). Tetraphenylporphyrin is designed as a four-arm initiator to afford the PDT function, which is employed to regulate the sequential polymerization of hydrophobic and hydrophilic monomers to produce star-shaped amphiphilic copolymers, followed by self-assembly in water to form unimolecular micelles. A functional monomer containing triplet pyridine ligand is prepared and introduced during the polymerization, which is to combine the radionuclide 177Lu to provide the RT function. The as-prepared unimolecular micelles exhibit high-temperature and pH stability, as expected. Satisfactory accumulation and retention efficiency in tumors and fast metabolism in organs are achieved, and PDT and RT can be conducted simultaneously to enhance the therapeutic effect toward tumors. This work provides a polymeric drug with bimodal therapy, including radiotherapy, which is expected to be competitive in the field of tumor treatment.

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Multi-Stimuli Responsive Sequence Defined Multi-Arm Star Diblock Copolymers for Controlled Drug Release

Cited by 4 publications

References 33 publications

One-pot strategy to access dynamic dual network from lignin-initiated star polymers by side reaction and transesterification

One-pot strategy to access dynamic dual network from lignin-initiated star polymers by side reaction and transesterification

Stimuli-Responsive Polymeric Nanocarriers Accelerate On-Demand Drug Release to Combat Glioblastoma

Preparation of Porphyrin-Based Unimolecular Micelles for Synergistic Photodynamic Therapy and Radiotherapy

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