Multi-stimuli responsive mesoporous silica-coated carbon nanoparticles for chemo-photothermal therapy of tumor

Lü, Hong‐Yan; Zhao, Qinfu; Wang, Xiudan; Mao, Yuling; Chen, Caishun; Gao, Yikun; Sun, Changshan; Wang, Siling

doi:10.1016/j.colsurfb.2020.110941

Cited by 57 publications

(22 citation statements)

References 41 publications

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“…The singlet oxygen generation and thermoresponsiveness of the loaded ICG in dimethylmaleic anhydride DMMA-modified PLL were efficient in destroying cancer cells. Figure 11 presents a multi-stimuli-responsive innovative system for controlled drug delivery, and thermal-chemotherapy for tumor treatment was described by Lu et al [136]. They obtained a novel mesoporous silica-coated carbon nanocomposite (DOX/MCN@Si-CDs) with redox/NIR/pH stimuli-responsive release ability and superior chemo-photothermal combined antitumor treatment activity as compared with individual treatments.…”

Section: Dual and Multi-responsive Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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Section: Dual and Multi-responsive Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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“…One of the most widely explored MSN-based combinational chemotherapy is the integration of phototherapeutics and chemotherapeutics [ 374 , 375 , 376 , 377 , 378 , 379 ]. Fang et al constructed dual-stimuli responsive 5-fluorouracil (5-FU)-loaded and indocyanine green (ICG)-conjugated mesoporous silica-coated gold nanorods (GNR@SiO 2 -5-FU-ICG) for the multimodal imaging-guided synergistic therapy [ 277 ].…”

Section: Update On Msn Applications In Nanomedicinesmentioning

confidence: 99%

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

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“…Zhang et al [112] synthesized a GSH-responsive probe using the fluorescent material amantadine-naphthalimide and the anticancer drug camptothecin to achieve active fluorescence imaging in cancer cells. Lu et al [113] used hollow mesoporous carbon (HMC) coated with doxorubicin and grafted reduction-sensitive near-infrared dye (HMC SS-CDPEI) to prepare a nanoprobe to monitor the release of doxorubicin. Choi et al [114] designed and synthesized a GSH-responsive fluorescent carbon nanoprobe.…”

Section: Fluorescent Nano-probe Design Based On Physiological Properties Of Gshmentioning

confidence: 99%

Nano-Drug Design Based on the Physiological Properties of Glutathione

2021

Molecules

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Glutathione (GSH) is involved in and regulates important physiological functions of the body as an essential antioxidant. GSH plays an important role in anti-oxidation, detoxification, anti-aging, enhancing immunity and anti-tumor activity. Herein, based on the physiological properties of GSH in different diseases, mainly including the strong reducibility of GSH, high GSH content in tumor cells, and the NADPH depletion when GSSH is reduced to GSH, we extensively report the design principles, effect, and potential problems of various nano-drugs in diabetes, cancer, nervous system diseases, fluorescent probes, imaging, and food. These studies make full use of the physiological and pathological value of GSH and develop excellent design methods of nano-drugs related to GSH, which shows important scientific significance and prominent application value for the related diseases research that GSH participates in or responds to.

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Multi-stimuli responsive mesoporous silica-coated carbon nanoparticles for chemo-photothermal therapy of tumor

Cited by 57 publications

References 41 publications

Smart Nanomaterials for Biomedical Applications—A Review

Smart Nanomaterials for Biomedical Applications—A Review

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

Nano-Drug Design Based on the Physiological Properties of Glutathione

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