Multi-stage screening to predict the specific anticancer activity of Ni(II) mixed-ligand complex on gastric cancer cells; biological activity, FTIR spectrum, DNA binding behavior and simulation studies

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

“…The results show that the diffraction peaks of the synthesized [Ln 2 (L) 3 ·H 2 O] n and the simulated peaks are in good agreement, which proves that the phase of [Ln 2 (L) 3 ·H 2 O] n is pure. [ 43 ]…”

Silver(I) Complexes with Mefenamic Acid and Nitrogen Heterocyclic Ligands: Synthesis, Characterization, and Biological Evaluation

“…Furthermore, many drugs contain N-heterocycles, and some have shown biological activity. − When N-heterocyclic compounds form complexes with metals, they also exhibit a variety of biological activities; nitrogen heterocyclic complexes have shown their ability to bind with DNA/BSA and exhibited anticancer activity. − Among them, the metal complexes formed by pyridine derivatives demonstrate good antitumor activity and multiple forms of antitumor applications. − A small amount of metal complexes produced by pyrazine derivatives also display anticancer activity. − …”

Synthesis, Characterization, Photoluminescence Properties and Antiproliferative Activity of New Pd(II), Ni(II) and Cu(II) Mixed Complexes Bearing Schiff Base Ligand and 1,10‐phenanthroline

“…[33] Previous studies have concluded that the capacity of certain Ni compounds to interact with DNA and generate DNA damage resulted in a reduction in the growth of cancer cells. [33,34] There were approximately 17.5 million new occurrences of cancer in 2015, and 8.7 million people died from tumor-related causes. [35] Cancer is considered malignant because it may develop and spread to other areas.…”

“…[31,32] Recently, the mixed ligand Ni(II) complexes have displayed a variety of biological activities, such as antiproliferative and anticancer properties. [33] Previous studies have concluded that the capacity of certain Ni compounds to interact with DNA and generate DNA damage resulted in a reduction in the growth of cancer cells. [33,34] There were approximately 17.5 million new occurrences of cancer in 2015, and 8.7 million people died from tumor-related causes.…”

“…Pd(II) complexes′ ability to inhibit cellular target DNA′s fast replication and ultimately lead to cell death is what underlies their anticancer effect [31,32] . Recently, the mixed ligand Ni(II) complexes have displayed a variety of biological activities, such as antiproliferative and anticancer properties [33] . Previous studies have concluded that the capacity of certain Ni compounds to interact with DNA and generate DNA damage resulted in a reduction in the growth of cancer cells [33,34] …”