Multi-spectral imaging of oxygen saturation

Savelieva, Tatiana A.; Stratonnikov, Aleksander A.; Loschenov, Victor B.

doi:10.1117/12.803905

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Therefore, four bandpass filters were employed to obtain a multispectral image. Following the measurement of the reflection coefficient, the obtained data were utilized to select the concentration of oxygenated and free hemoglobin, as well as hemoglobin oxygen saturation [108].…”

Section: Computer Simulationmentioning

confidence: 99%

Devices and Methods for Dosimetry of Personalized Photodynamic Therapy of Tumors: A Review on Recent Trends

Alekseeva,

Makarov,

Efendiev

et al. 2024

Cancers

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Significance: Despite the widespread use of photodynamic therapy in clinical practice, there is a lack of personalized methods for assessing the sufficiency of photodynamic exposure on tumors, depending on tissue parameters that change during light irradiation. This can lead to different treatment results. Aim: The objective of this article was to conduct a comprehensive review of devices and methods employed for the implicit dosimetric monitoring of personalized photodynamic therapy for tumors. Methods: The review included 88 peer-reviewed research articles published between January 2010 and April 2024 that employed implicit monitoring methods, such as fluorescence imaging and diffuse reflectance spectroscopy. Additionally, it encompassed computer modeling methods that are most often and successfully used in preclinical and clinical practice to predict treatment outcomes. The Internet search engine Google Scholar and the Scopus database were used to search the literature for relevant articles. Results: The review analyzed and compared the results of 88 peer-reviewed research articles presenting various methods of implicit dosimetry during photodynamic therapy. The most prominent wavelengths for PDT are in the visible and near-infrared spectral range such as 405, 630, 660, and 690 nm. Conclusions: The problem of developing an accurate, reliable, and easily implemented dosimetry method for photodynamic therapy remains a current problem, since determining the effective light dose for a specific tumor is a decisive factor in achieving a positive treatment outcome.

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Section: Computer Simulationmentioning

confidence: 99%

Devices and Methods for Dosimetry of Personalized Photodynamic Therapy of Tumors: A Review on Recent Trends

Alekseeva,

Makarov,

Efendiev

et al. 2024

Cancers

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“…A background image is captured where none of the LEDs are turned on, and is subtracted from NIR images to account for ambient light. The MSI system utilizes a previously developed scatter model to calculate StO2 values of the experimental phantoms [17]. The calculated StO2 values were compared to those of control phantoms measured with spectrophotometer.…”

Section: Multi-spectral Imaging (Msi) Systemmentioning

confidence: 99%

Calibration of Spectral Imaging Devices With Oxygenation-Controlled Phantoms: Introducing a Simple Gel-Based Hemoglobin Model

Manser

Gurm

et al. 2019

Front. Phys.

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An optical phantom model with stable oxygen saturation (StO2) and optical properties (OPs) is the key for quick and accurate calibration of spectral imaging devices. Toward this goal, we have developed gel-based phantoms using Agarose, polystyrene microsphere, purified hemoglobin, and yeast. Theoretical values of OPs were calculated by applying Beer Lambert law and Mie theory whereas a robust fitting algorithm was used to extract StO2. Stability of OPs and StO2 in the phantoms was validated experimentally over a period of 2 weeks and the effect of pre-heating at 65 • C degrees on StO2 was observed. Multi-spectral imaging (750, 780, 850, and 945 nm) of the phantoms were also performed on the FDA-approved commercial system to demonstrate the utility of the phantoms.

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“…Careful selection of spectral bands enables the assessment of a wide range of tissue and blood chromophores such as oxy-hemoglobin, deoxy-hemoglobin and bilirubin, and the choice of wavelengths in the near infrared spectrum compared to the visible spectrum provide some added depth discrimination to measurements 3 . In addition spectral imaging has the advantage that it can be applied noninvasively which is useful for applications such as assessment of burns or inflammatory skin conditions [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Real-time megapixel multispectral bioimaging

et al. 2010

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Spectral imaging involves capturing images at multiple wavelengths resulting in a data cube (x, y, λ) that allows materials to be identified by its spectral signature. While hyperspectral imagers can provide high spectral resolution, they also have major drawbacks such as cost, size, and the copious amounts of data in the image cube. Typically, the complete hyperspectral data cube provides little additional information compared to only 3-8 discrete (multiwavelength) imaging bands. We present two new approaches and related technologies where we are able to acquire spectral imaging data stacks quickly and cost-effectively. Our two spectral imaging systems represent different approaches integrated with standard CCD and CMOS imagers: sequential rotating filter wheels (RFWs) and lithographically patterned dichroic filter arrays (DFAs). The RFW approach offers the ability for rapid configuration of a spectral system, and a whole new level of self-contained image acquisition, processing and on-board display. The DFA approach offers the potential for ultra compact imagers with acquisition of images of multiple wavelengths simultaneously, while still allowing for processing and display steps to be built into the camera. Both approaches lend themselves production of multi-wavelength/spectral imaging systems with differing features and advantages.

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Multi-spectral imaging of oxygen saturation

Cited by 3 publications

References 4 publications

Devices and Methods for Dosimetry of Personalized Photodynamic Therapy of Tumors: A Review on Recent Trends

Devices and Methods for Dosimetry of Personalized Photodynamic Therapy of Tumors: A Review on Recent Trends

Calibration of Spectral Imaging Devices With Oxygenation-Controlled Phantoms: Introducing a Simple Gel-Based Hemoglobin Model

Real-time megapixel multispectral bioimaging

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