Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation

Tunable Assembly of Organic–Inorganic Molecules into Hierarchical Superstructures as Ligase Mimics for Enhancing Tumor Photothermal Therapy

“…When the reaction solution contains absorption spectroscopy with characteristic peaks at 370 and 652 nm. [50,51] As shown in Figure S18 (Supporting Information), no oxidation reaction occurred in the mixture which contains only TMB and H 2 O 2 . However, the solution gradually turns to blue color after the addition of HSPSzyme into TMB-H 2 O 2 solution (Figure 4B).…”

Recent Advances in Nanozymes: From Matters to Bioapplications

“…[ 197 ] Recently, we are manufacturing a highly integrated manganese dioxide encapsulated selenium‐melanin (Se@Me@MnO 2 ) nanozyme to scavenge intracellular ROS (Figure 14D). [ 198 ] The Se@Me@MnO 2 nanozyme was fabricated by the radical polymerization and the in situ oxidation‐reduction reaction sequentially. This multi‐shell nanozyme can efficiently scavenging of H 2 O 2 , HO • , and O 2 •− with troika‐like synergistic effects of SOD, CAT, and GPx‐like mimic activities.…”

“…It achieves synergetic anti-oxidative efficacy to protect cellular components against harmful oxidative damage. [197] Recently, we are manufacturing a highly integrated manganese dioxide encapsulated selenium-melanin (Se@Me@MnO 2 ) nanozyme to Anti-oxidant Ceria nanoparticles SOD/CAT Protect against ischemic stroke [191] Ceria nanoparticles SOD Acquired SOD-scavenging ability [192] Fluoride-capped nanoceria Oxidase Highly oxidase-mimicking efficient [193] Nanoceria DNase I As DNase I like enzyme for cleaving of single-stranded DNA oligonucleotides [194] Prussian blue nanoparticle POD/CAT/SOD Multienzyme mimetics for scavenging of ROS [195] V 2 O 5 @pDA@MnO 2 GPx/SOD/CAT Multi-nanozymes to mimic intracellular anti-oxidant defense system [196] Se@pDA GPx Biomimetic anti-oxidant machinery [197] Se@Me@MnO 2 GPx/SOD/CAT Multienzyme mimetics for efficient intracellular anti-oxidation [198] Disease treatment Ec-pE@MNP SOD Fenton-like bioreactor for tumor therapy [205] DMSN-Au-Fe 3 O 4 GOx/POD Paves a way for nanocatalytic tumor therapy [206] HMON-Au@Cu-TA GOx Enhancing ROS-mediated anti-tumor efficacy [207] GOD-Fe 3 O 4 @DMSNs GOD Catalytic nanomedicine by approaching selectivity and efficiency concurrently for tumor therapeutics [208] Ce6@MnO 2 -PEG POD Modulation of hypoxia and enhance PDT [209] PtFe@Fe 3 O 4 POD/CAT Dual enzyme-like activities for deep pancreatic cancer therapy [210] Polydopamine nanoparticles POD/SOD Efficient scavengers for ROS in periodontal disease [211] Anti-bacterial MoS 2 -hydrogel POD Improve the anti-bacterial performance of nanozymes [217] PCN-224-Ag-HA POD Surface-adaptive, on-demand nanoplatform for synergistic bacteria killing, and wound disinfection [218] RCMs POD Defect-rich adhesive and efficient for bacterial inhibition [219] Sensing 3D GH-5 POD Enhanced nanozyme activity for glucose detection [221] Pt, Ru, and Ir nanoparticles POD Detecting versatile analytes from small molecules to proteins and cells [222] AuMS POD Selective colorimetric detection of dopamine [223] Pd-Ir NPs@GVs POD Ultrasensitive colorimetric assay of disease biomarkers [224] CeO 2 nanoparticles Phosphatase Highly sensitive chemiluminescent sensing of intracellular Al 3+ [228] Imaging AMP NRs POD For intelligent, accurate, and noninvasive cancer therano...…”

“…© 2021 Wiley-VCH GmbH scavenge intracellular ROS (Figure 14D). [198] The Se@Me@ MnO 2 nanozyme was fabricated by the radical polymerization and the in situ oxidation-reduction reaction sequentially. This multi-shell nanozyme can efficiently scavenging of H 2 O 2 , HO • , and O 2…”

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

“…Indeed, these catalytic materials produced ROS by decomposition of H 2 O 2 in both acidic and basic condition, resulting in good anticancer behavior as well as cancer cell detection. Building on these advancements in dual nanozymes and their efficacy in tumor treatment, Ai et al fabricated a manganese dioxide encapsulated selenium-melanin (Se@Me@MnO 2 ) multishell nanozyme for intracellular antioxidation [108]. Se@Me@MnO 2 nanozyme exhibits multiple enzyme activities such as CAT, SOD and glutathione peroxidase (GPx).…”