Multi-Responsive Nanocarriers Based on β-CD-PNIPAM Star Polymer Coated MSN-SS-Fc Composite Particles

Guo, Feng; Li, Guiying; Ma, Shenggui; Zhou, Hengquan; Chen, Xinyi

doi:10.3390/polym11101716

Cited by 21 publications

(3 citation statements)

References 34 publications

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“…This activation is triggered by the conformational change of conjugated polymeric ligands [ 41 ]. Poly (N-isopropyl acrylamide) (PNIPAM) is one of the widely recognized and extensively used temperature-sensitive polymers in scientific research [ 42 ]. Its conjugation to MSNs has been explored to enhance the thermo-responsive characteristics of the nanoplatforms.…”

Section: Mesoporous Silica Nanoparticles (Msns)mentioning

confidence: 99%

Mesoporous Silica Nanoparticles: Types, Synthesis, Role in the Treatment of Alzheimer’s Disease, and Other Applications

Sivamaruthi,

Kapoor,

Kukkar

et al. 2023

Pharmaceutics

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Globally, many individuals struggle with Alzheimer’s disease (AD), an unrelenting and incapacitating neurodegenerative condition. Despite notable research endeavors, effective remedies for AD remain constrained, prompting the exploration of innovative therapeutic avenues. Within this context, silica-based nanoplatforms have emerged with pronounced potential due to their unique attributes like expansive surface area, customizable pore dimensions, and compatibility with living systems. These nanoplatforms hold promise as prospective interventions for AD. This assessment provides a comprehensive overview encompassing various forms of mesoporous silica nanoparticles (MSNs), techniques for formulation, and their applications in biomedicine. A significant feature lies in their ability to precisely guide and control the transport of therapeutic agents to the brain, facilitated by the adaptability of these nanoplatforms as drug carriers. Their utility as tools for early detection and monitoring of AD is investigated. Challenges and prospects associated with harnessing MSNs are studied, underscoring the imperative of stringent safety evaluations and optimization of how they interact with the body. Additionally, the incorporation of multifunctional attributes like imaging and targeting components is emphasized to enhance their efficacy within the intricate milieu of AD. As the battle against the profound repercussions of AD persists, MSNs emerge as a promising avenue with the potential to propel the development of viable therapeutic interventions.

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Section: Mesoporous Silica Nanoparticles (Msns)mentioning

confidence: 99%

Mesoporous Silica Nanoparticles: Types, Synthesis, Role in the Treatment of Alzheimer’s Disease, and Other Applications

Sivamaruthi,

Kapoor,

Kukkar

et al. 2023

Pharmaceutics

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“…Therapeutic system could aid in non-invasive monitoring of both disease progression and nanoparticle delivery pathways, 4 Theranostic nanomedicine includes the utilization of theranostics with nanosizes and numerous capabilities such as targeted drug delivery, sustained/controlled release, greater transport productivity by means of endocytosis, stimuli responsive frameworks and the combination of therapeutic approaches such as multimodality determination and treatment, 5 Theranostics refers to the pairing of diagnostic biomarkers with therapeutic agent, 6 Such nanotheranostics are Polymer nanoparticles (NP), 7 dendrimers, 8 liposomes, 9 carbon-based nanomaterials, 10 metallic or inorganic Nanocarriers 11 and systems that integrate both categories, namely H. Polymercoated nanocarriers. 12,13 Carbon Carbon nanotubebased nanomaterials (alone) or decorated with other materials, 14,15 graphene oxide, 16,17 fullerenes, carbon quantum dots 18 used to detect drugs in biological samples. Their imagery Prussian blue dice are octahedral metal Hexacyanoferrate developed for detection Tools with conductive and magnetic properties.…”

Section: Introductionmentioning

confidence: 99%

Nanotheranostics: A powerful next-generation solution to tackle the chronic disease

Gandhi,

Boghara

2024

IJCAAP

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The use of nanotheranostics is the most advanced diagnostic and therapeutic techniques for a variety of disorders like cancer, IDs, HIV has drawn significant interest in the last ten years. Currently, various methods are use in the development of bright nanotheranostics, which mix bioactive concentrating on particular tissues and diagnostic capabilities. By using nanotheranostics, keeping track the therapy responses in real-time and therapeutic drugs is delivered. As a result, there is less chance of consuming too much medication. Several non-intrusive Imaging methods have been applied to track the medication distribution processes quantitatively. Radiolabeling of nanoparticles is a popular and effective method of nuclear diagnostics imaging in medicine. Numerous nanoparticles really have been created and they have effective qualities, they were created for imaging tumors and other lesions because of their effective qualities. Multifunctional nanotheranostics have been described for inorganic nanoparticles like gold, silver, silica-based nanomaterials, or organic nanoparticles including polymers, carbon-based nanomaterials, and liposomes. A summary of the most recent nanotheranostics organized according to the utilized nanomaterials is provided. Finally, as material scientists who work in the field of nanotheranostics can use this review as a guide to create newer and more effective nanotheranostics, it can be advantageous to the medical and pharmaceutical communities as well as of society.

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“…Such nanotheranostics can be obtained from polymeric nanoparticles (NPs) [7] , dendrimers [8] , liposomes [9] , carbon based nanomaterials [10] , metal or inorganic nanocarriers [11] and systems which integrate both of such categories i.e. polymeric coated nanocarriers [12 , 13] . Carbon based nanomaterials, as carbon nanotubes either alone or decorated with other materials [14 , 15] , graphene oxide [16] , [17] , [18] , fullerenes, carbon quantum dots [19] , have been employed for the detection of drugs in biological samples or their imaging ability.…”

Section: Introductionmentioning

confidence: 99%

Current update on nanoplatforms as therapeutic and diagnostic tools: A review for the materials used as nanotheranostics and imaging modalities

Sıafaka

Okur

Karantas

et al. 2021

Asian Journal of Pharmaceutical Sciences

107

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In the last decade, the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases, especially cancer, is held great attention. Up to date, several approaches have been employed in order to develop smart nanotheranostics, which combine bioactive targeting on specific tissues as well as diagnostic properties. The nanotheranostics can deliver therapeutic agents by concomitantly monitor the therapy response in real-time. Consequently, the possibility of over- or under-dosing is decreased. Various non-invasive imaging techniques have been used to quantitatively monitor the drug delivery processes. Radiolabeling of nanomaterials is widely used as powerful diagnostic approach on nuclear medicine imaging. In fact, various radiolabeled nanomaterials have been designed and developed for imaging tumors and other lesions due to their efficient characteristics. Inorganic nanoparticles as gold, silver, silica based nanomaterials or organic nanoparticles as polymers, carbon based nanomaterials, liposomes have been reported as multifunctional nanotheranostics. In this review, the imaging modalities according to their use in various diseases are summarized, providing special details for radiolabeling. In further, the most current nanotheranostics categorized via the used nanomaterials are also summed up. To conclude, this review can be beneficial for medical and pharmaceutical society as well as material scientists who work in the field of nanotheranostics since they can use this research as guide for producing newer and more efficient nanotheranostics.

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Multi-Responsive Nanocarriers Based on β-CD-PNIPAM Star Polymer Coated MSN-SS-Fc Composite Particles

Cited by 21 publications

References 34 publications

Mesoporous Silica Nanoparticles: Types, Synthesis, Role in the Treatment of Alzheimer’s Disease, and Other Applications

Mesoporous Silica Nanoparticles: Types, Synthesis, Role in the Treatment of Alzheimer’s Disease, and Other Applications

Nanotheranostics: A powerful next-generation solution to tackle the chronic disease

Current update on nanoplatforms as therapeutic and diagnostic tools: A review for the materials used as nanotheranostics and imaging modalities

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