Multi-responsive drug release from hydrogen-bonding multilayers containing PEGylated nanoparticles and azobenzenes

Abstract

We report the design of a platform that is assembled within hydrogen-bonding nanoparticle/azobenzene multilayer films for multi-responsive drug release.

Stimuli‐Responsive Free‐Standing Layer‐By‐Layer Films

“…A popular and productive approach to multi­responsive materials is to integrate different reactive moieties into individual polymer chains, often taking advantage of controlled and living polymerization techniques . Films prepared by the LbL technique can also respond to multiple stimuli, such as polymer/clay LbL films, polymer/gold nanoparticles multilayers, composites of poly(ethylene glycol)‐functionalized nanoparticles and photochromic polymers, and capsules comprising star polyelectrolytes . This communication describes several examples of an approach to designing multiresponsive LbL films that relies on compartmentalizing chemistry in stratified polyelectrolyte multilayer (PEM) films such that different external stimuli perform different functions.…”

Multi-Stimuli-Responsive Polymer Materials: Particles, Films, and Bulk Gels

“…The obtained multilayer films could respond to light, pH, and ionic strength. The multi‐stimuli‐responsive properties made them interesting candidates to serve as multifunctional nanocarriers and coatings 246…”

Novel multi-responsive polymer materials: When ionic liquids step in

“…In many cases, a wide rang of multiple stimuli-responsive materials has been designed for drug delivery systems, where the basic structures and residual substances are mostly required for biocompatibility or biodegradability [2,5,[12][13][14]. Many other applications such as the detection, optical data storage, and sensing applications require the electrochemically active material to a certain extent while maintaining their original shape.…”

“…Conventional "smart" polymers, in most of the cases, express stimuli-responsive properties mainly stemming from the intrinsic properties of the functional groups as well as the movement and rearrangement of the polymer chain segment [1][2][3][4]. For example, the photo-responsive property of azobenzene, a popular chromophore, is based on the photoinduced trans-cis isomerization [5]. Homopolymers or copolymers of N-isopropylacrylamide (NIPAM) are the main examples of thermosensitive materials.…”

“…Their potential applications in various fields including drug delivery [2,5,12,13], imaging [14], sensors [15,16], functional coats [17], catalysis [18] have been inspiring researchers to discover novel MRPMs processing routes in two main directions: exploring novel responsive polymers and investigating the effects of various interactions at the molecular level under different circumstances [19][20][21][22][23].…”