Multi-residue analysis of pharmaceuticals in wastewater by liquid chromatography–magnetic sector mass spectrometry: Method quality assessment and application in a Belgian case study

Vergeynst, Leendert; Haeck, Ashley; Wispelaere, Patrick De; Langenhove, Herman Van; Demeestere, Kristof

doi:10.1016/j.chemosphere.2014.03.069

Cited by 97 publications

(41 citation statements)

References 31 publications

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“…ZDV had the highest measured concentration in both influent and effluent followed by 3TC and NVP. The influent concentrations of 3TC and ZDV were much lower than what has been reported in other countries for example in Belgium and Germany 507 ng/L and 380 ng/L were measured for 3TC and ZDV, respectively 16,17 . The concentration of NVP reported in the current study compared the study by Prasse et.al.…”

Section: Wwtp Influent and Effluent Watermentioning

confidence: 59%

“…In this regard, various antiretroviral and antibiotic regimens are used to manage HIV and other HIV induced infections 14,15 . Due to low HIV prevalence in developed countries, analyses of antiretroviral drugs have not yet received a lot of attention but recent studies in Belgium and Germany have documented environmentally significant concentrations in both surface waters and WWTP effluents 16,17 .…”

Section: Introductionmentioning

confidence: 99%

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A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-MS/MS and matrix-matched standards

et al. 2016

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Tuhkanen, T. (2016). A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-MS/MS and matrix-matched standards. Analytical Methods, 8 (37), 6720-6729. doi:10.1039 AbstractAn analytical method for simultaneous determination of seven commonly used antibiotics and three antiretrovirals in surface water and urban wastewater at ng/L level has been developed. The method involves concentration and clean-up by solid phase extraction (SPE) followed by identification and quantification by liquid chromatography tandem mass spectrometry (LC-ESI-MS/MS). The use of matrix-matched calibration curves constructed by spiking surface water was evaluated for quantification and compared with the internal standard method using isotopically labelled compounds. The method gave absolute recoveries of 41-116% with most of the compounds having recoveries >50%. The LOQ ranged from 5-63 ng/L allowing for determination of the analytes at trace levels in the environmental samples considered. The difference in the quantification results obtained using surface water matrix-matched standards and internal standards were within ±20% margin.The method provides an affordable and relatively fast alternative with acceptable accuracy and precision. The method was applied to study the occurrence of the target analytes in surface water of Lake Päijänne and wastewater from Jyväskylä wastewater treatment plant (WWTP) in Central Finland. All target compounds were detected in the WWTP streams with concentration ranging between 10-570 ng/L while low ng/L levels were measured for some of the analytes in surface waters. The results institutes the need for further monitoring in in other WWTP streams and receiving waters as well as improvements of the wastewater treatment process with the aim of minimizing the pharmaceutical load in the effluents.

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Section: Wwtp Influent and Effluent Watermentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-MS/MS and matrix-matched standards

et al. 2016

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“…Secondly, the determination of detection limits in complex matrices such as wastewater can be problematic for compounds that are ubiquitously present and for which no true blank matrix samples can be found [6,7]. Thirdly, different factors such as stability of analytes and standards, linearity, matrix effects and recovery can vary from compound to compound and from sample to sample.…”

Section: Introductionmentioning

confidence: 99%

“…Decision 2002/657/EC [8], Eurachem Guide [9], review articles [10,11]), strategies specifically dealing with measurement uncertainty in the context of environmental multi-residue quantification are only sporadically investigated [7].…”

Section: Introductionmentioning

confidence: 99%

Statistical procedures for the determination of linearity, detection limits and measurement uncertainty: A deeper look into SPE-LC-Orbitrap mass spectrometry of pharmaceuticals in wastewater

Vergeynst

K'Oreje

Wispelaere

et al. 2017

Journal of Hazardous Materials

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“…The lingering question of whether the relative low environmental concentration levels of pharmaceuticals would cause adverse effects in humans or wildlife remains unsolved. In France, monitoring programs have clearly emphasised the ubiquity of the contamination by pharmaceuticals from various therapeutic classes: veterinary and human, prescribed and non-prescribed, licit and illicit, and in a wide range of concentrations [2][3][4][5][6][7][8]. The need to "display of robust monitoring and methods for a comprehensive assessment of the status of water bodies are essential elements for sound water management" has been reinforced [9].…”

Section: Contextmentioning

confidence: 99%

Development and implementation of a Di-MS based method with full uncertainty estimate to achieve measurement of pharmaceutical residus in natural waters

Lardy-Fontan¹,

Brieudes²,

Candido³

et al. 2015

17th International Congress of Metrology

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Abstract. The need for effective chemical water monitoring is evident. Indeed the overall management and decision making system driven by the Water Framework Directive (WFD) and other European water policies is strongly dependent on monitoring data. Because the overall decision making process relies, most of the time, on acquired data, it puts considerable pressures on the display of high quality chemical environmental measurements. However, performing fit for purpose measurements implies i) the demonstration of their metrological traceability ii), the evidence of their achievement thanks to accurate and sensitive analytical methods and iii) their statement with a realistic estimate of expanded uncertainty are thoroughly addressed. Concern regarding the presence of potentially active substances in surface waters was brought up by the end of the 90s. Intensive monitoring programs have revealed a chronic state of contamination of water systems by numerous molecules; pharmaceuticals have been highlighted as one of first concern for French aquatic system. This work demonstrates the consequences that (i) the sampling strategy and (ii) methodological and (iii) metrological laboratory choices may have on the measurements' result. It reemphasizes that the main contribution to the uncertainty of measurement is linked to sampling uncertainty

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Multi-residue analysis of pharmaceuticals in wastewater by liquid chromatography–magnetic sector mass spectrometry: Method quality assessment and application in a Belgian case study

Cited by 97 publications

References 31 publications

A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-MS/MS and matrix-matched standards

A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-MS/MS and matrix-matched standards

Statistical procedures for the determination of linearity, detection limits and measurement uncertainty: A deeper look into SPE-LC-Orbitrap mass spectrometry of pharmaceuticals in wastewater

Development and implementation of a Di-MS based method with full uncertainty estimate to achieve measurement of pharmaceutical residus in natural waters

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