High-concentration photovoltaics (HCPV) is a highly promising technology to directly convert plentiful solar en ergy to electricity. However, even for the most advanced HCPVs, about 60% of the concentrated solar energy is rejected as waste heat; therefore, it is desirable to utilize the massive waste heat from HCPV modules. Considering the nature of low-grade waste thermal energy, a microscale organic Rankine cycle (MaRC) offers a promising solution. In a subcritical MaRC, subcooled refrigerant is usually pumped into a microchannel heat sink of each multi-junction photovoltaic cell. In this paper, a complete microchannel flow boiling model is developed based on distributed mass, energy and momentum conservation laws. Detailed MaRC thermal-fluid analysis is conducted to evaluate the effects of working fluid, inlet subcooling, axial fluid/cell temperature distribution and critical heat flux on cogeneration efficiency. The performance analysis indicates that the HCPV/MORC system can achieve a net 8.8% increase of power generation efficiency in comparison to liquid-cooled HCPV at ambi ent temperature. The proposed HCPV /MaRC configuration shows great promise in large-scale applications of HCPV solar power generation. A cross-sectional area (m2) Dh hydraulic diameter (m) G mass flux (kg/m2-s) h specific enthalpy (J/kg) L channel length (m) m mass flowrate (kg/s) p channel perimeter (m) P absolute pressure (Pa) Q heat load (W) r vapor core radius (m) s specific entropy (J/kg-K) T temperature (0C) V volume (m3) W work (W) z channel location (m)