Multi-organ Involvement of Sweet's Syndrome: A Case Report and Literature Review

Abstract

The hallmark of Sweet's syndrome (SS) is the infiltration of mature neutrophils in the upper dermis. We herein report a case of SS with multi-organ involvement. A 32-year-old man presented with fever, anemia and dyspnea. He was given antibiotics, without any improvements. Later, a number of erythematous lesions appeared, accompanied by deteriorating respiratory and cardiovascular functions. A diagnosis of SS was confirmed on a skin biopsy, and the patient was given corticosteroids, the dose of which was reduced after one month. The organ function subsequently deteriorated, and he ultimately died of multi-organ failure. Early recognition of SS with multi-organ involvement is important in patients with SS.

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

“…Sweet syndrome can affect many organs as an extracutaneous manifestation, particularly in patients with a malignancy of an extracutaneous site, which has been reported in approximately 50% of cases [ 6 ], or in patients with multiorgan affection [ 16 ]. The most common extracutaneous sites are the lungs; symptoms vary from flu-like symptoms in upper respiratory tract infection at disease onset, to acute respiratory distress syndrome.…”

Sweet's Syndrome Induced by Granulocyte Colony-Stimulating Factor: Case Report

“…Genellikle kemoterapi sonrasında nötrofil üretimini stimüle ederek nötropenik dönemi kısaltmak amacıyla kullanılmakta ve ilaca bağlı SS hastalarında önemli bir yer teşkil etmektedir. 5,9 Ancak özellikle hematolojik malignitesi olan ve G-CSF kullanan hastalarda SS'ye yol açan nedeni saptamak için şüpheli ilacın kesilmesi önerilmektedir. Nitekim ilaç ilişkili SS tanısında klasik tipteki 2 majör kriter, 38 o C'nin üzerinde ateş, ilaç kullanımı ile klinik bulgular arasında zamansal tutarlılık, ilacın kesilmesi ile lezyonlarda iyileşme görülmesi veya ilacın tekrar alımı ile nüks şeklinde 5 tanı kriterinin tamamlanması gerekmektedir.…”

“…Pulmoner tutulum ise nadirdir. 5 Olgumuzda yapılan ileri incelemeler sonrası multiorgan tutulumu saptanmamıştır.…”

“…Ancak malignite ilişkili SS'nin her iki cinste eşit oranda ya da erkek cinsiyette daha sık gözlendiği bildirilmiştir. 5,6 Bu çalışmada, splenik marjinal zon lenfoma tanısı ile izlenen, nötropeni nedeni ile granülosit koloni stimüle edici faktör [granulocyte colony stimulating factor (G-CSF)] tedavisi verilen ve izleyen dönemde SS gelişen bir olgu sunulmuştur.…”

Sweet´s syndrome and pancreatic neoplasm: an atypical association

“…weet's syndrome (SS) or acute febrile neutrophilic dermatosis, is a rare inflammatory condition characterized by fever, neutrophilia, and abrupt onset of painful erythematous nodules or plaques, 1,2,3 a dermal infiltrate of mature neutrophils on histology and a fast response to the steroidal treatment. 4,5 It has an incidence of 3 cases per million persons-year 6 , and predominates in women (female-male ratio, 4:1). 3,7 Malignancy is associated with SS in approximately 20% of cases, 8 being the hematological tumors the most frequently associated (85%), 7 and on the other hand, nearly two-third of the patients with an association with solid tumors have carcinoma of genitourinary organs.…”