Multi-omics analysis reveals therapeutic effects of Bacillus subtilis-fermented Astragalus membranaceus in hyperuricemia via modulation of gut microbiota

Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

“…SCr and BUN are two important indicators of renal dysfunction. [40][41][42] To verify the nephroprotective effect of the as-fabricated core-shell structured MNs, the SCr and BUN levels were determined by standard Cr and BUN biochemical assay kits. As expected, the SCr level of mice treated with coreshell structured MNs shows a remarkable decrease within 5 h and maintained lower levels even after administration of 24 h, suggesting an excellent protective effect on the renal function (Fig.…”

Advances in fermented foods revealed by multi-omics: A new direction toward precisely clarifying the roles of microorganisms

“…Therefore, a multi-omics approach is adopted to systematically track specific genes that produce specific active constituents in fermented foods ( Cocolin et al, 2018 ); these data are then combined with the final phenotype using transcriptomes and proteomes, further enhancing the understanding of fermented food systems. Wang et al (2023) established a murine model of hyperuricemia to explore the effective treatment ability of Bacillus subtilis -fermented Astragalus using a multi-omics approach, which revealed that the abundance of butyrate-producing bacteria ( Odoribacter splanchnicus and Collinsella tanakaei ) and probiotics ( Lactobacillus enterocolitica and Bacillus mycoides ) increased significantly during fermentation, thereby effectively reducing kidney inflammation and regulating the expression of uric acid transporters to treat hyperuricemia. Using a multi-omics approach, it is more affordable to identify genes and gene products responsible for the functional metabolites in fermented foods, yielding highly active metabolites for human health ( Lee et al, 2021 ).…”

Optimizing the scale-up production of fermented astragalus and its benefits to the performance and egg quality of laying hens

“…Astragalus ( Astragalus membranaceus ) is a perennial medicinal herb, whose root has been used as a traditional Chinese medicine for centuries, according to the Compendium of Materia Medica . This book noted various health benefits provided by the high medicinal value of astragalus, making it one of the top-favored homologous medicines and foods in China (Wang et al, 2023 ). Astragalus has also been widely applied as a supplement in the poultry farming industry to confer a variety benefits to hosts.…”

“…When L. plantarum -FA was added to the diet of broilers, it improved their growth performance and serum biochemical parameters, as well as the performance and serum antioxidant ability of laying hens (Qiao et al, 2018a ; Shi et al, 2020 ). Moreover, B. subtilis -FA exhibited therapeutic effects on hyperuricemia via modulation of gut microbiota in mice models (Wang et al, 2023 ). Fermentation is thus an effective method to increase the content of bioactive substances in astragalus, and FA could be utilized as a feed additive for poultries and even as a potential medicine for some illnesses to relieve symptoms.…”