Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

Wang, Rui; Sun, Yanfang; Wang, Han; Liu, Tianqi; Shavandi, Amin; Nie, Lei; Yunusov, Khaydar E.; Jiang, Guohua

doi:10.1039/d3tb02607h

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02607h

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Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

Rui Wang,

Yanfang Sun,

Han Wang

et al.

Abstract: An appropriate non-oral platform via transdermal delivery of drugs is highly recommended for the treatment of hyperuricemia. Herein, a core-shell structured microneedle array patch with programmed drug release functions was designed to regulate serum...

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Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment

Yang,

Guo,

Lei

et al. 2024

Regenerative Biomaterials

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The skin stratum corneum (SC) barrier function will interfere with the absorption of topical treatment and reduce the drug's therapeutic effect on alopecia. Microneedles (MNs) can penetrate the skin barrier and deliver drugs to the dermis. Furthermore, MNs can mechanically stimulate the skin, which promotes hair growth. Thus, we designed a green and dissolvable composite microneedle made of hyaluronic acid (HA) and Bletilla striata polysaccharide (BSP) to encapsulate cholesterol-free ginsenoside Rg3 liposomes (Rg3-LPs) to avoid cholesterol metabolism-producing testosterone to inhibit hair regeneration and minimize the effect of the SC barrier on liposomes absorption. HA and BSP can enhance the mechanical strength of Rg3-MNs to ensure the transport of liposomes to the hair follicle region (HF) while causing minimal skin irritation and guaranteeing cell compatibility. In addition, HA increased hair density and was more conducive to hair regeneration. In telogen effluvium (TE) and testosterone-induced androgenetic alopecia (AGA) animals, Rg3-MNs achieved comparable efficacy to minoxidil with low-frequency treatment, and the quality of regenerated hair was higher. Furthermore, quantitative characterization and transcriptome sequencing results showed that Rg3-MNs promoted hair regeneration by promoting the expression of Wnt3a and Wnt10b genes, activating the Wnt/β-catenin pathway. Therefore, Rg3-MNs present broad prospects in the treatment of alopecia.

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Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment

Yang,

Guo,

Lei

et al. 2024

Regenerative Biomaterials

View full text Add to dashboard Cite

show abstract

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Core–shell structured microneedles with programmed drug release functions for prolonged hyperuricemia management

Abstract: An appropriate non-oral platform via transdermal delivery of drugs is highly recommended for the treatment of hyperuricemia. Herein, a core-shell structured microneedle array patch with programmed drug release functions was designed to regulate serum...

Cited by 1 publication

References 49 publications

Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment

Dissolvable microneedles loaded ginsenoside Rg3 liposome: a transdermal delivery approach for alopecia treatment

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