Multi-modal 3D imaging of radionuclides using multiple hybrid Compton cameras

Omata, Akihisa; Masubuchi, Miho; Koshikawa, N.; Kataoka, J.; Kato, Hirohisa; Toyoshima, Atsushi; Teramoto, Tokuo; Ooe, Kazuhiro; Liu, Yuwei; Matsunaga, Keiko; Kamiya, Takashi; Watabe, Tadashi; Shimosegawa, Eku; Hatazawa, Jun

doi:10.1038/s41598-022-06401-6

Cited by 15 publications

(9 citation statements)

References 45 publications

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“…According to the few published works on this topic (e.g., [73]), extremely large absorbers would be needed, otherwise truncation artifacts might deteriorate the image. Alternatively, rotating the Compton camera [74] or using two or more Compton-camera heads at different angular positions [75] can also enlarge angular coverage and thus reduce truncation artifacts. Some compensation for data truncation can be reached using statistical iterative reconstruction methods in combination with very accurate models (see below).…”

Section: Image Reconstructionmentioning

confidence: 99%

Hybrid PET/Compton-camera imaging: an imager for the next generation

Llosá

Rafecas

2023

Eur. Phys. J. Plus

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Compton cameras can offer advantages over gamma cameras for some applications, since they are well suited for multitracer imaging and for imaging high-energy radiotracers, such as those employed in radionuclide therapy. While in conventional clinical settings state-of-the-art Compton cameras cannot compete with well-established methods such as PET and SPECT, there are specific scenarios in which they can constitute an advantageous alternative. The combination of PET and Compton imaging can benefit from the improved resolution and sensitivity of current PET technology and, at the same time, overcome PET limitations in the use of multiple radiotracers. Such a system can provide simultaneous assessment of different radiotracers under identical conditions and reduce errors associated with physical factors that can change between acquisitions. Advances are being made both in instrumentation developments combining PET and Compton cameras for multimodal or three-gamma imaging systems, and in image reconstruction, addressing the challenges imposed by the combination of the two modalities or the new techniques. This review article summarizes the advances made in Compton cameras for medical imaging and their combination with PET.

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Section: Image Reconstructionmentioning

confidence: 99%

Hybrid PET/Compton-camera imaging: an imager for the next generation

Llosá

Rafecas

2023

Eur. Phys. J. Plus

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“…A group of Yoshihara et al (2017) and Uenomachi et al (2018), used Compton cameras to carry out CGC imaging. While other groups used Compton PET hybrid detectors to realize the CGC imaging (Omata et al, 2020;Omata et al, 2022). Finally, another group of researchers employed TOF information to determine the location of source emission via simulation (Chiang et al, 2020).…”

Section: Recent Work In Cgc Imagingmentioning

confidence: 99%

“…By visualizing the reconstructed images, the images using pinhole mode had better resolution compared to their corresponding images acquired by Compton. Again, in their subsequent research paper, they developed a hybrid Compton camera (HCC) that contains three imaging modalities in a single case: Compton, pinhole, and PET imaging (Omata et al, 2022). The developed system consists of four HCCs to extend pinhole/Compton imaging to 3D space as illustrated in Figure 17.…”

Section: Cgc Imager Based On Compton Scattering Kineticsmentioning

confidence: 99%

“…Results showed that simultaneous imaging of 137 Cs (Compton mode targeting 662 keV), 22 Na (PET mode targeting 511 keV), and 241 Am (pinhole mode targeting 60 keV) within the same field of view was possible (Figure 18). Through the analysis of 1D projections of each source, which are coded as green, red, and blue conversions correspond to 137 Cs (662 keV; Compton mode), 22 Na (PET mode), and 241 Am (60 keV; pinhole mode) sources, the Compton mode still suffer for poor resolution, followed by pinhole mode, while PET mode is reported to have good image resolution as its 1D projection is not broad (Omata et al, 2022). In addition, the imaging of 67 Ga and 111 In, which are used in various diagnostic scenarios was conducted.…”

Section: Cgc Imager Based On Compton Scattering Kineticsmentioning

confidence: 99%

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Review of the Imaging Performance and the Current Status of the Cascade Gamma-Rays Coincidence Imagers

Nkuba

Junior

Mohamed

et al. 2022

TJET

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Various studies that have investigated the detection of gamma coincidence events have revealed that design factors and image reconstruction approaches dictate the spatial resolution, coincidence efficiency, and levels of statistical noise of the detection system. In the case of imaging, cascade gamma-ray coincidence (CGC) imagers coupled with collimated detectors offer promising values for both spatial resolution and coincidence efficiency. However, to date, no CGC imager with single or multiple collimated detectors has reported a performance level beyond 6.7 mm spatial resolution (FWHM) and 6.0 ×1ncidence efficiency. Given the recent developments and the current interests in high resolution and localization of an individual decaying nucleus, there is a need for CGC imagers with higher performance in terms of spatial resolution and efficiency. Therefore, deploying a CGC imager coupled with multiple collimated detectors may prove to be of value in nuclear imaging and probably in clinical applications

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“…Although many issues associated with gamma-ray glows have been discussed, the question of where and how such glows develop in clouds remains unclear, as no gamma-ray images have been obtained to date. Gamma-ray imaging of sub-MeV to several MeV is generally difficult, but high-sensitivity Compton cameras have been developed for use in the fields of medicine, astrophysics, and even for environmental surveys (e.g., Hosokoshi et al, 2019;Kataoka et al, 2013;Koide et al, 2018;Omata et al, 2020Omata et al, , 2022Schonfelder et al, 1984). In this study, we provide the first challenge of direct imaging of gamma-ray glows using a Compton camera during 2021-2022 winter in Japan.…”

mentioning

confidence: 99%

Compton Camera Imaging of a Gamma‐Ray Glow From a Thunderstorm

Kuriyama

Masubuchi

Koshikawa

et al. 2022

Geophysical Research Letters

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Gamma‐ray glows associated with thunderclouds have been observed since the 1980s, however it remains unclear how, and at which thunderstorms gamma‐ray glows are generated in dense atmospheres. In this study, we report the first Compton camera imaging of a gamma‐ray glow from a winter thundercloud. On 14 January 2022, using two identical Bi4Ge3O12 scintillators in energy range of 0.05–5 MeV, we detected two gamma‐ray glows lasting ∼4 min in a mountain area 25 km from the Japan Sea and 410 m above sea level. The same events were also observed by the Compton camera, where the first glow we observed suggested statistically significant (4.0 and 5.9 σ level) signals of two enhanced concentrations in gamma‐ray photon images in a range of 0.15–1.5 MeV. These concentrations were most clearly observed in a time window of Δt = 50 s around the peak intensity of the gamma‐ray glow.

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Multi-modal 3D imaging of radionuclides using multiple hybrid Compton cameras

Cited by 15 publications

References 45 publications

Hybrid PET/Compton-camera imaging: an imager for the next generation

Hybrid PET/Compton-camera imaging: an imager for the next generation

Review of the Imaging Performance and the Current Status of the Cascade Gamma-Rays Coincidence Imagers

Compton Camera Imaging of a Gamma‐Ray Glow From a Thunderstorm

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