Various studies that have investigated the detection of gamma coincidence events have revealed that design factors and image reconstruction approaches dictate the spatial resolution, coincidence efficiency, and levels of statistical noise of the detection system. In the case of imaging, cascade gamma-ray coincidence (CGC) imagers coupled with collimated detectors offer promising values for both spatial resolution and coincidence efficiency. However, to date, no CGC imager with single or multiple collimated detectors has reported a performance level beyond 6.7 mm spatial resolution (FWHM) and 6.0 ×1ncidence efficiency. Given the recent developments and the current interests in high resolution and localization of an individual decaying nucleus, there is a need for CGC imagers with higher performance in terms of spatial resolution and efficiency. Therefore, deploying a CGC imager coupled with multiple collimated detectors may prove to be of value in nuclear imaging and probably in clinical applications
The purpose of this study was to simulate the GSO detector of a micro PET using GATE simulation platform. The performance and responses of the simulated GSO detector assembly were evaluated by comparing the simulated data to the experimental and XCOM data to validate the simulation platform and procedure. Based on NEMA NU-4 2008 protocols, the performance of GSO detector in terms of sensitivity was simulated and compared to the experimental data. Similarly, the GSO detector response to photons interaction was simulated and compared against the XCOM data for absorbed intensity ratio in the GSO detector and survived intensity ratio in Pb blocks. Results showed that simulated and experimental sensitivities agreed well with R2 of 0.995 and two overlapping bands at 95% confidence. An agreement with R2 of 0.972 and 0.973 as well as with overlapping bands at 95% confidence was obtained in simulated and XCOM data for absorbed and survived intensity ratio in the GSO detector and Pb blocks, respectively. The observed agreements demonstrate the accuracy of the simulation method to mimic the behaviour of the GSO detector. The validated GATE algorithm for micro PET scanner is therefore recommended for simulation and optimisation of collimator design in further studies. Keywords: GATE simulation, Experimental data, XCOM data, GSO detector, micro PET.
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