Multi-liposomal containers

Yaroslavov, Alexander A.; Sybachin, Andrey V.; Zaborova, Olga V.; Зезин, А. Б.; Talmon, Yeshayahu; Ballauff, Matthias; Menger, F. M.

doi:10.1016/j.cis.2015.08.011

Cited by 29 publications

(9 citation statements)

References 40 publications

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“…Also, due to the fact that the organization of tumor tissue differs from that of healthy tissue by the presence of defects such as gaps between endothelial cells (usually over 200–300 nm), an effect of increased permeability takes place so that nanosized micelles are able to penetrate and accumulate in tumors. This effect of accumulation in an area of inflammation is named ‘passive targeting’ 26 . An additional benefit of the application of polylactide micelles is their stability at 35–37 °С in physiological media 12,27 …”

Section: Introductionmentioning

confidence: 99%

Magneto‐sensitive and enzymatic hydrolysis‐resistant systems for the targeted delivery of paclitaxel based on polylactide micelles with an external polyethylene oxide corona

Pigareva

Alekhina

Grozdova

et al. 2021

Polymer International

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Poly(d,l‐lactide)‐b‐(ethylene glycol) micelles with a mean diameter of 20 nm and a narrow size distribution were obtained by film rehydration. The incorporation of a hydrophobic drug, paclitaxel, into the micelles was studied via various physicochemical methods – dynamic and static light scattering, transmission electron microscopy and infrared spectroscopy. The loading of the hydrophobic drug did not change the morphology of the micelles. By means of MTT tests it was found that, encapsulated in the micelles, paclitaxel retained its activity towards MCF7 cancer cells with cytotoxicity equal to that of commercial drug Taxol®. Modification of the micelles with maghemite nanoparticles resulted in the formation of magneto‐sensitive micelles with fast response to an external magnetic field: saturation magnetization, 0.6 emu g−1; residual magnetization, 0.1 emu g−1; coercive force, 67.5 Oe. The obtained micelles demonstrated high colloidal stability in a wide range of pH during a long period. A study of the behavior of the empty micelles and micelles loaded with paclitaxel and maghemite in the presence of a specific enzyme – proteinase K – showed that micelles underwent hydrolysis only after a long induction period. The obtained results indicate that maghemite‐modified poly(d,l‐lactide)‐b‐(ethylene oxide) micelles are promising for controlled delivery of hydrophobic drugs. © 2021 Society of Industrial Chemistry.

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Section: Introductionmentioning

confidence: 99%

Magneto‐sensitive and enzymatic hydrolysis‐resistant systems for the targeted delivery of paclitaxel based on polylactide micelles with an external polyethylene oxide corona

Pigareva

Alekhina

Grozdova

et al. 2021

Polymer International

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“…The physicochemical properties of liposomes can be modified by altering the phospholipids themselves or their ratio. Since dipalmitoyl phosphatidylcholine (DPPC) was the most pH-stable liposome found, with a sustained drug release at physiological pH ( Yaroslavov et al, 2015 ), DPPC was selected as the carrier of curcumin to explore the therapeutic effect in human fetal astrocyte cell line SVGA model of neuroinflammation and reactive astrogliosis. Compared with free curcumin, LipoCur showed a significant downregulation of glial cell proliferation genes and a lower level of pro-inflammatory cytokines including IL-6, IL-1β, TGF-β, and TNF-α ( Schmitt et al, 2020 ).…”

Section: Organic Npsmentioning

confidence: 99%

Nanoparticles: A Hope for the Treatment of Inflammation in CNS

Zhu

et al. 2021

Front. Pharmacol.

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Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a main hallmark of common neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), among others. The over-activated microglia release pro-inflammatory cytokines, which induces neuronal death and accelerates neurodegeneration. Therefore, inhibition of microglia over-activation and microglia-mediated neuroinflammation has been a promising strategy for the treatment of neurodegenerative diseases. Many drugs have shown promising therapeutic effects on microglia and inflammation. However, the blood–brain barrier (BBB)—a natural barrier preventing brain tissue from contact with harmful plasma components—seriously hinders drug delivery to the microglial cells in CNS. As an emerging useful therapeutic tool in CNS-related diseases, nanoparticles (NPs) have been widely applied in biomedical fields for use in diagnosis, biosensing and drug delivery. Recently, many NPs have been reported to be useful vehicles for anti-inflammatory drugs across the BBB to inhibit the over-activation of microglia and neuroinflammation. Therefore, NPs with good biodegradability and biocompatibility have the potential to be developed as an effective and minimally invasive carrier to help other drugs cross the BBB or as a therapeutic agent for the treatment of neuroinflammation-mediated neurodegenerative diseases. In this review, we summarized various nanoparticles applied in CNS, and their mechanisms and effects in the modulation of inflammation responses in neurodegenerative diseases, providing insights and suggestions for the use of NPs in the treatment of neuroinflammation-related neurodegenerative diseases.

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“…This finding corroborates with the occurrence of flip-flop of anionic lipids induced by the polycation adsorption. The flip-flop mediates an increase in the anionic lipid molar fraction in the outer layer of the liposomal membrane; the adsorption of polycation induces the lateral segregation of anionic lipids, 34 and consequently, increase of the concentration of lipid trigger in the unaffected surface area. Thus the pH-induced release from the complexes of anionic fliposomes with polycation should be more effective in the system with flip-flop of anionic lipids, as the higher concentration of lipid trigger leads to the higher concentration of the defects formed in response to the change in pH.…”

Section: Tunable Ph-induced Release -Acceleration Of the Release Ratementioning

confidence: 99%

“…Previously, we studied the interaction of branched polycations (brush-like 32 or star-shaped 33 ) with anionic fliposomes and showed an increase in the rate and amount of the content release. However, the adsorption of the branched polycations induces the transmembrane migration (flip-flop) of the anionic lipids from the inner to the outer layer of a liposomal membrane, 34 thus causing the formation of undesirable defects inside the membrane and limiting the application of such constructions for drug delivery. We decided to use linear polylysine, to prevent the formation of the undesirable defects upon adsorption of the polycation on the surface of anionic fliposomes as this polymer does not induce flip-flop of the anionic lipids.…”

Section: Introductionmentioning

confidence: 99%

<p>Modification of fliposomes with a polycation can enhance the control of pH-induced release</p>

Lokova

Zaborova

2019

IJN

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PurposeNowadays, the development of stimuli-sensitive nanocontainers for targeted drug delivery is of great value. Encapsulation of a drug in a pH-sensitive liposomal container not only provides protective and transport functions, but also helps to create a system with a controlled release mechanism.MethodsIn this study, we investigated the influence of a cationic polypeptide on the pH-induced release of anticancer drug doxorubicin (DXR) from the anionic fliposomes – liposomes consisting of a neutral lipid, an anionic lipid (prone to interact with a polycation), and a lipid trigger (imparting the pH-sensitivity).ResultsFirst, we showed the possibility to control the pH-induced release by the simple modification of the anionic fliposomes with linear polylysine. Second, we optimized the fliposomal composition such that the obtained fliposomes responded to the pH changes only when complexed with the polycation (“turning on” the release). Finally, pH-induced release from the polylysine-modified anionic fliposomes was tested on an anticancer drug DXR.ConclusionWe have succeeded in developing “smart” stimuli-sensitive nanocontainers capable of tunable controlled release of a drug. Moreover, based on the data on release of a low molecular salt, one can predict the release profile of DXR.

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Multi-liposomal containers

Cited by 29 publications

References 40 publications

Magneto‐sensitive and enzymatic hydrolysis‐resistant systems for the targeted delivery of paclitaxel based on polylactide micelles with an external polyethylene oxide corona

Magneto‐sensitive and enzymatic hydrolysis‐resistant systems for the targeted delivery of paclitaxel based on polylactide micelles with an external polyethylene oxide corona

Nanoparticles: A Hope for the Treatment of Inflammation in CNS

<p>Modification of fliposomes with a polycation can enhance the control of pH-induced release</p>

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