Multi-level analysis of bacteria isolated from inpatients in respiratory departments in China

Tang, Xiang; Xiao, Meng; Zhuo, Chao; Xu, Yingchun; Zhong, Nanshan

doi:10.21037/jtd.2018.04.46

Cited by 23 publications

(29 citation statements)

References 27 publications

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“…But at present, the rate of blood culture in Chinese patients with LRIs was not high. A multicenter study from China showed that blood culture isolates accounted for only 5.3% of all specimen types [1][2]. For LRIs, should we do blood culture or sputum culture?…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Lower respiratory tract infections (LRIs) were the most common infectious disease of respiratory tract [1][2]. Irrational use of antibiotics would delay the patient's condition and cause serious bacterial resistance [1][2]. According to the data from China Antimicrobial Resistance Surveillance System (CARSS) in 2015, the major specimen type from inpatients in respiratory departments in China were sputum (81.6%, 41,131/50,417) [1][2].…”

Section: Introductionmentioning

confidence: 99%

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Pathogenic Characteristics of Sputum and Bronchoalveolar Lavage Fluid Samples from Patients with Lower Respiratory Tract Infection

Peng

Zhou

Tian

2020

Preprint

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Background Lower respiratory tract infections(LRIs)were a very common disease, no matter in community acquired infection or hospital acquired infection. Sputum and bronchoalveolar lavage fluid (BALF) were the most important specimens of LRIs. The choice of antibiotics for the treatment of LRIs usually depended on the results of antimicrobial sensitivity of bacteria isolated from sputum and BALF. However, it was rarely reported to compare the pathogens isolated from sputum and BALF and the difference of antimicrobial sensitivity.Methods A retrospective study was conducted to analyze the differences between sputum and BALF samples in pathogen isolation and antimicrobial sensitivity in our hospital.Results In our hospital during 2013–2015 year, the quality evaluation of sputum samples was not conducted before sputum culture, but in 2016–2018 year, the quality evaluation of sputum samples was conducted firstly and only qualified sputum samples were cultured. The results of pathogen culture showed that Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus and Haemophilus influenzae were the top five pathogens isolated from sputum and BALF. Antimicrobial susceptibility test showed for these five pathogens the susceptibility rates of BALF isolates to most antibiotics were higher than those isolated from sputum. The sensitivity of A. baumannii to common antibiotics was less than 50%. In particular, the detection rate of carbapenem resistant A. baumannii (CR-ABA) in sputum and BALF was higher than 80%. The sensitivity of P. aeruginosa to antibiotics other than ticarcillin/clavulanic acid and minocycline were higher than 50%. The detection rate of carbapenem resistant Klebsiella pneumoniae (CR-KPN) was 10% − 20% in 2013–2015 and 30% − 50% in 2016–2018. The detection rate of MRSA in sputum was higher than 80%, while that in BALF was 65% − 70%. The separation rate of beta-lactamase-negative ampicillin-resistant H. influenzae (BLNAR) was between 0–6%.Conclusions The sensitivity of strains isolated from BALF to commonly used antibiotics was generally higher than that from sputum. MRSA, CR-KPN and A. baumannii were the focus of infection control for LRIs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathogenic Characteristics of Sputum and Bronchoalveolar Lavage Fluid Samples from Patients with Lower Respiratory Tract Infection

Peng

Zhou

Tian

2020

Preprint

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“…Lower respiratory tract infections (LRIs) were the most common infectious disease of respiratory tract. [1][2] Pneumonia was the second most common infection in hospitalized patients, and was highly correlated with morbidity and mortality. [3] Irrational use of antibiotics would delay the patient's condition and cause serious bacterial resistance.…”

Section: Introductionmentioning

confidence: 99%

“…[3] Irrational use of antibiotics would delay the patient's condition and cause serious bacterial resistance. [1][2] According to the data from China Antimicrobial Resistance Surveillance System (CARSS) in 2015, the major specimens type from inpatients in respiratory departments in China were sputum (81.6%, 41,131/50,417). [1][2] Due to the convenience of specimens collection, sputum had always been the most common type of specimens in clinical microbiology laboratories in China.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the results of sputum culture and bronchoscopic lavage fluid culture:an analysis report of large sample size data from the Clinical Microbiology Laboratory

Tian¹,

Zhang²,

He³

et al. 2019

Preprint

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Background Sputum specimens were the most common for Clinical Microbiology Laboratory in China. For the results of sputum culture, it was difficult for clinicians to evaluate the significance, and even more difficult for laboratory physicians. At present, most Clinical Microbiology Laboratories in China executed quality assessment of sputum specimens. But how to evaluate the results of sputum culture was still very confusing. To solve this problem, we conducted a series of retrospective studies.Methods Based on the culture results of bronchoscopic lavage fluid (BALF), the differences of sputum culture results before (2013-2015) and after (2016-2018) quality control of sputum samples in our hospital were compared.Results Pseudomonas aeruginosa , Acinetobacter baumannii , Klebsiella pneumoniae and Staphylococcus aureus were the four most common pathogens in sputum and BALF culture, both in 2013-2015 years and 2016-2018 years. Antimicrobial susceptibility test from 2013-2015 and 2016-2018 both showed for P. aeruginosa and K. pneumoniae , the susceptibility rates of BALF isolates to all commonly used antibiotics were higher than those from sputum. For A. baumannii and S. aureus , the sensitivity rates of BALF isolates to most antibiotics were higher than those from sputum. After quality control of sputum samples, there was still a difference between the results of sputum culture and those of BALF.Conclusions Even though the quality control of sputum specimens had been carried out, the results of culture and antimicrobial resistance of pathogens from qualified sputum samples were still different from those of BALF.

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Fine particulate matter alters the microecology of the murine respiratory tract

Yang

Zou

et al. 2019

Environ Sci Pollut Res

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Multi-level analysis of bacteria isolated from inpatients in respiratory departments in China

Abstract: In China, the predominant bacterial pathogens in the respiratory ward were and non-fermentative bacteria. High prevalence of ESBL-EC and ESBL-KP isolated from lower respiratory tract (LRT) was revealed in primary hospitals and pediatric patients.

Cited by 23 publications

References 27 publications

Pathogenic Characteristics of Sputum and Bronchoalveolar Lavage Fluid Samples from Patients with Lower Respiratory Tract Infection

Pathogenic Characteristics of Sputum and Bronchoalveolar Lavage Fluid Samples from Patients with Lower Respiratory Tract Infection

Comparison of the results of sputum culture and bronchoscopic lavage fluid culture:an analysis report of large sample size data from the Clinical Microbiology Laboratory

Fine particulate matter alters the microecology of the murine respiratory tract

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