Multi-Layered Hydrogels for Biomedical Applications

Liu, Guiting; Ding, Zhangfan; Yuan, Qijuan; Xie, Huixu; Gu, Zhipeng

doi:10.3389/fchem.2018.00439

Cited by 52 publications

(38 citation statements)

References 67 publications

(68 reference statements)

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“…Over the years, various polymeric biomaterials have been developed by adding multiple functional groups in their molecular structure to control the physical, chemical, and biological characteristics of these scaffolds [22,23,24,25]. They are processed using materials both natural and synthetic in origin, derived from sources like algae, animals, micro-organisms [19] and synthetic biomaterials derived either from lactic acid, caprolactone, or glycoside monomers [26,27]. Though several scaffold matrices were introduced, which had sufficient qualities to provide necessary support and properties required for tissue growth, they had inadequate cell mimicking property and limited interaction with stromal cells which were crucial in promoting tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

et al. 2019

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The field of regenerative medicine has tremendous potential for improved treatment outcomes and has been stimulated by advances made in bioengineering over the last few decades. The strategies of engineering tissues and assembling functional constructs that are capable of restoring, retaining, and revitalizing lost tissues and organs have impacted the whole spectrum of medicine and health care. Techniques to combine biomimetic materials, cells, and bioactive molecules play a decisive role in promoting the regeneration of damaged tissues or as therapeutic systems. Hydrogels have been used as one of the most common tissue engineering scaffolds over the past two decades due to their ability to maintain a distinct 3D structure, to provide mechanical support for the cells in the engineered tissues, and to simulate the native extracellular matrix. The high water content of hydrogels can provide an ideal environment for cell survival, and structure which mimics the native tissues. Hydrogel systems have been serving as a supportive matrix for cell immobilization and growth factor delivery. This review outlines a brief description of the properties, structure, synthesis and fabrication methods, applications, and future perspectives of smart hydrogels in tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

et al. 2019

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“…Hydrogel-based dressing materials provide hydration to wounds and accelerate the healing process for faster pain relief. Different base materials are reported to be used for hydrogel preparation (Liu et al, 2018). Here, a curd-extracted peptide pool is used as the base material for the formulation of hydrogel.…”

Section: Discussionmentioning

confidence: 99%

Curd-Peptide Based Novel Hydrogel Inhibits Biofilm Formation, Quorum Sensing, Swimming Mortility of Multi-Antibiotic Resistant Clinical Isolates and Accelerates Wound Healing Activity

2019

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The search for a bioactive natural antibacterial agent with wound healing properties is a common practice for the development of new-generation molecules. Antimicrobial peptides are a good alternative to antibiotics and easy-to-form hydrogels under self-assembled conditions without pH adjustment. With this in mind, the peptide pool was extracted from a formulated curd composed of a blend of probiotic bacteria such as Streptococcus thermophilus , Lactobacillus casei , and Bifidobacterium bifidum at an optimized ratio of 7:1:2. The water content of curd was collected by the drainage column, centrifuged, filtered through a 0.45-μM filter, and used for hydrogel preparation. Matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry (MS) analysis confirmed the presence of peptide pool in the extracted water. The prepared hydrogel was freeze dried, and its effect on biofilm formation, swarming mortality, antimicrobials, wound healing, and biocompatibility was subsequently verified. Transmission electron microscope (TEM) and scanning electron microscope (SEM) images revealed the fibrous network of peptides after self-assembly with non-polar n-hexane solvent and a porous structure after drying, respectively. The observed biocompatibility, antimicrobial activity, and strong wound healing activity of the developed curd-based hydrogel have opened a new platform for antibacterial ointment formulation.

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“… 21 However, it is possible to make hierarchical hydrogels containing different layers with specific mechanical properties to mimic living-like tissues. 22 Organs, for example, are spatially heterogeneous in terms of composition and, therefore, different cell types coexist within them. Consequently, multilayered hydrogels with different mechanical properties are of interest as an excellent option for 3D scaffold construction for tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Characterization of Multilayered Hydrogels: A Rheological Study for 3D-Printed Systems

et al. 2021

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We describe rheological protocols to study layered and three-dimensional (3D)-printed gels. Our methods allow us to measure the properties at different depths and determine the contribution of each layer to the resulting combined properties of the gels. We show that there are differences when using different measuring systems for rheological measurement, which directly affects the resulting properties being measured. These methods allow us to measure the gel properties after printing, rather than having to rely on the assumption that there is no change in properties from a preprinted gel. We show that the rheological properties of fluorenylmethoxycarbonyl-diphenylalanine (FmocFF) gels are heavily influenced by the printing process.

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Multi-Layered Hydrogels for Biomedical Applications

Cited by 52 publications

References 67 publications

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

Curd-Peptide Based Novel Hydrogel Inhibits Biofilm Formation, Quorum Sensing, Swimming Mortility of Multi-Antibiotic Resistant Clinical Isolates and Accelerates Wound Healing Activity

Mechanical Characterization of Multilayered Hydrogels: A Rheological Study for 3D-Printed Systems

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