Multi-ingredient, Caffeine-containing Dietary Supplements: History, Safety, and Efficacy

Gurley, Bill J.; Steelman, Susan; Thomas, Sheila L.

doi:10.1016/j.clinthera.2014.08.012

Cited by 69 publications

(51 citation statements)

References 241 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous study of Navy and Marine Corp personnel, dietary supplement use was strongly associated with increasing resistance training duration [65]. Many dietary supplements contain caffeine, and the caffeine content of some of these can be very high [66,67]. Accurately determining the caffeine content of dietary supplements is difficult because manufacturers are not required to list the amount of caffeine on their supplement facts labels, amounts are usually not available on company websites, and if the ingredients are proprietary the manufacturer is not required to list caffeine at all [67].…”

Section: Discussionmentioning

confidence: 99%

Caffeine Use among Active Duty Navy and Marine Corps Personnel

et al. 2016

View full text Add to dashboard Cite

Data from the National Health and Nutrition Examination Survey (NHANES) indicate 89% of Americans regularly consume caffeine, but these data do not include military personnel. This cross-sectional study examined caffeine use in Navy and Marine Corps personnel, including prevalence, amount of daily consumption, and factors associated with use. A random sample of Navy and Marine Corps personnel was contacted and asked to complete a detailed questionnaire describing their use of caffeine-containing substances, in addition to their demographic, military, and lifestyle characteristics. A total of 1708 service members (SMs) completed the questionnaire. Overall, 87% reported using caffeinated beverages ≥1 time/week, with caffeine users consuming a mean ± standard error of 226 ± 5 mg/day (242 ± 7 mg/day for men, 183 ± 8 mg/day for women). The most commonly consumed caffeinated beverages (% users) were coffee (65%), colas (54%), teas (40%), and energy drinks (28%). Multivariable logistic regression modeling indicated that characteristics independently associated with caffeine use (≥1 time/week) included older age, white race/ethnicity, higher alcohol consumption, and participating in less resistance training. Prevalence of caffeine use in these SMs was similar to that reported in civilian investigations, but daily consumption (mg/day) was higher.

show abstract

Section: Discussionmentioning

confidence: 99%

Caffeine Use among Active Duty Navy and Marine Corps Personnel

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A moderate amount of caffeine intake is benecial for human health, as strong evidence reveals that caffeine is associated with a reduced risk of many diseases such as Parkinson's disease, Alzheimer's disease, type 2 diabetes, depression, and cancer of the liver and endometrium. [3][4][5] Caffeine is currently the most routinely ingested bioactive compound, and exists in a variety of caffeine-containing beverages include tea, coffee, so drinks, and energy drinks, as well as in caffeinated food products. However, despite the growing demand for healthy green caffeine production, this valuable chemical is mainly manufactured by chemical synthesis, which is associated with environmental pollution.…”

Section: Introductionmentioning

confidence: 99%

Engineering a novel biosynthetic pathway in Escherichia coli for the production of caffeine

Sun

Pan

et al. 2017

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…Caffeine is considered the major stimulatory constituent of energy drinks while sugars and other substances such as guarana, taurine, and ginseng are added, often with combinations of vitamins, to formulate different blends [1, 2]. Energy drinks have become an accepted means to increase cognitive ability, memory, alertness, physical performance and cardiovascular output [3–10].…”

Section: Introductionmentioning

confidence: 99%

“…Energy drinks have become an accepted means to increase cognitive ability, memory, alertness, physical performance and cardiovascular output [3–10]. But while energy drink use continues to rise, concerns have been raised about their high caffeine content and with it, the risks associated with their consumption particularly by young people [1, 8, 11–15]. The use of guarana and other plant-based materials can further increase the caffeine content and general stimulant properties offered by these beverages, but because they are considered herbal supplements, these plant-based additives are not subject to the same reporting requirements as are sugars and caffeine.…”

Section: Introductionmentioning

confidence: 99%

Guarana Provides Additional Stimulation over Caffeine Alone in the Planarian Model

et al. 2015

View full text Add to dashboard Cite

The stimulant effect of energy drinks is primarily attributed to the caffeine they contain. Many energy drinks also contain other ingredients that might enhance the tonic effects of these caffeinated beverages. One of these additives is guarana. Guarana is a climbing plant native to the Amazon whose seeds contain approximately four times the amount of caffeine found in coffee beans. The mix of other natural chemicals contained in guarana seeds is thought to heighten the stimulant effects of guarana over caffeine alone. Yet, despite the growing use of guarana as an additive in energy drinks, and a burgeoning market for it as a nutritional supplement, the science examining guarana and how it affects other dietary ingredients is lacking. To appreciate the stimulant effects of guarana and other natural products, a straightforward model to investigate their physiological properties is needed. The planarian provides such a system. The locomotor activity and convulsive response of planarians with substance exposure has been shown to provide an excellent system to measure the effects of drug stimulation, addiction and withdrawal. To gauge the stimulant effects of guarana we studied how it altered the locomotor activity of the planarian species Dugesia tigrina. We report evidence that guarana seeds provide additional stimulation over caffeine alone, and document the changes to this stimulation in the context of both caffeine and glucose.

show abstract

Multi-ingredient, Caffeine-containing Dietary Supplements: History, Safety, and Efficacy

Cited by 69 publications

References 241 publications

Caffeine Use among Active Duty Navy and Marine Corps Personnel

Caffeine Use among Active Duty Navy and Marine Corps Personnel

Engineering a novel biosynthetic pathway in Escherichia coli for the production of caffeine

Guarana Provides Additional Stimulation over Caffeine Alone in the Planarian Model

Contact Info

Product

Resources

About