Multi‐Functional Carbon Dots for Visualizing and Modulating ROS‐Induced Mitophagy in Living Cells

Li, Hao; Guo, Jing; Liu, Aikun; Chen, Yue; He, Yejun; Qu, Junle; Yan, Wei; Song, Jun

doi:10.1002/adfm.202212141

Cited by 9 publications

(3 citation statements)

References 65 publications

(74 reference statements)

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“…75 Moreover, the utilization of lower doses of drugs in a combination therapy may cause fewer side effects and better results than monotherapy. Leveraging tunable surface chemistry, CDs can be combined with immunoadjuvants, photosensitizers, or chemotherapeutic drugs for immunotherapy, chemotherapy, and phototherapies, 76,77 or a combination thereof. Furthermore, CDs capable of generating free radicals can be useful in photodynamic therapy (PDT).…”

Section: Biomedical Applications Of Nir-ii Cdsmentioning

confidence: 99%

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Yang,

Han,

Bianco

et al. 2024

ACS Nano

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Second near-infrared (NIR-II) carbon dots, with absorption or emission between 1000 and 1700 nm, are gaining increasing attention in the biomaterial field due to their distinctive properties, which include straightforward preparation processes, stable photophysical characteristics, excellent biocompatibility, and low cost. As a result, there is a growing focus on the controlled synthesis and modulation of the photochemical and photophysical properties of NIR-II carbon dots, with the aim to further expand their biomedical applications, a current research hotspot. This account aims to provide a comprehensive overview of the recent advancements in NIR-II carbon dots within the biomedical field. The review will cover the following topics: (i) the design, synthesis, and purification of NIR-II carbon dots, (ii) the surface modification strategies, and (iii) the biomedical applications, particularly in the domain of cancer theranostics. Additionally, this account addresses the challenges encountered by NIR-II carbon dots and will outline future directions in the realm of cancer theranostics. By exploring carbon-based NIR-II biomaterials, we can anticipate that this contribution will garner increased attention and contribute to the development of next-generation advanced functional carbon dots, thereby offering enhanced tools and strategies in the biomedical field.

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Section: Biomedical Applications Of Nir-ii Cdsmentioning

confidence: 99%

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Yang,

Han,

Bianco

et al. 2024

ACS Nano

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“…The above study may provide a powerful tool and a new strategy for ROS‐induced mitochondrial phagocytosis‐induced mitochondrial injury diseases. [ 140 ]…”

Section: Biomedical Applications Of Cdsmentioning

confidence: 99%

Deep‐Red to Near‐Infrared Carbon Dots in Biosensing and Bio‐medical Applications

Huang

Chen

et al. 2023

Chin. J. Chem.

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Comprehensive SummaryWith the rapid development in the field of biomedical diagnosis and treatment, carbon dots (CDs) with favorable photostability, biocompatibility and high quantum yields for deep‐red to near‐infrared emission have attracted the attention of a majority of researchers. By enlarging the sp2 domain in the core of CDs, doping them with heteroatoms like nitrogen and sulfur, applying hydrothermal, electrochemical, or microwave‐assisted techniques, CDs can be made with the aforementioned photoemission capabilities. In view of these excellent properties, CDs are flourishing in biosensing and biomedical applications, so that a thorough description and discussion of this topic is beneficial to capture the up‐to‐date progress of CDs in this field, providing suggestions and considerations for readers.

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“…As a new family member of carbon materials, CPDs have excellent fluorescent properties, low toxicity, high stability, and good biocompatibility . These advantages enable CPDs to be extensively used in fluorescence sensing, bioimaging, supercapacitors, drug carriers, optoelectronic devices, and photocatalysis. − Various raw materials can serve as precursors to prepare CPDs . The reaction process allows CPDs to inherit the structures and properties of precursors, such as lipophilicity. , Among the many types of CPDs that have been reported, only a few types of CPDs are able to target subcellular organelles in cells, receiving increasing attention .…”

Section: Introductionmentioning

confidence: 99%

Multicolor Lipid Droplet-Targeted Carbonized Polymer Dots with Luminescence Regulation for Bioimaging Applications

Yu,

Huo,

et al. 2024

ACS Appl. Nano Mater.

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Color-tunable, lipid droplet-targeted carbonized polymer dots (CPDs) were fabricated by varying reaction precursors through one-pot solvothermal synthesis. They exhibit gradual luminescence ranging from red to blue via the separation of the reaction products by means of column chromatography. We analyzed the structures of these multicolor CPDs and discovered that their emission wavelengths are regulated by both particle size and surface state. The blueshifts of their emission wavelength from 630 to 500 nm can be attributed to the band gap change, primarily manifested by an increase in N content, a decrease in O content, and a difference in grain size. Multiple photophysical parameters reveal that the synthesized CPDs have excellent luminescent properties. Fluorescence colocalization imaging of our full-color CPDs with lipid droplet-type commercial dyes yielded satisfactory results, displaying no cross-color with commercial dyes. Also, they were feasible for full-color lipid-droplet-targeted in vivo bioimaging of zebrafish, highlighting the lipid-rich yolk sac of zebrafish embryos. In conclusion, these nanoprobes exhibit significant promise in investigating lipid droplet metabolism regulation and offer the benefits of good biocompatibility, ease of fabrication, and lipophilicity.

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Multi‐Functional Carbon Dots for Visualizing and Modulating ROS‐Induced Mitophagy in Living Cells

Cited by 9 publications

References 65 publications

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Recent Progress on Second Near-Infrared Emitting Carbon Dots in Biomedicine

Deep‐Red to Near‐Infrared Carbon Dots in Biosensing and Bio‐medical Applications

Multicolor Lipid Droplet-Targeted Carbonized Polymer Dots with Luminescence Regulation for Bioimaging Applications

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