Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair

Abstract

Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations, such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair; it is very challenging to combine these functions into a material. Herein, we report the first photothermal (PT) effect in bismuth (Bi)-doped glasses. On the basis of this discovery, we have developed a new type of Bi-doped bioactive glass that integrates both functions, thus reducing the number of treatment cycles. We demonstrate that Bi-doped bioglasses (BGs) provide high PT efficiency, potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization. The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence (PL) or depolymerizing glass networks. In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation, differentiation, and mineralization. Upon illumination with near-infrared (NIR) light, the bioglass (BG) can efficiently kill bone tumor cells, as demonstrated via in vitro and in vivo experiments. This indicates excellent potential for the integration of multiple functions within the new materials, which will aid in the development and application of novel biomaterials.

Micropatterning Decellularized ECM as a Bioactive Surface to Guide Cell Alignment, Proliferation, and Migration

“…A significant portion of tissue engineering research focuses on the ability to derive native biological structures as biomaterials for regenerative purposes [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Biomimetic structures, in particular, strive to recreate naturally regenerative microenvironments to promote desired cell behavior and mitigate inflammatory responses [ 9 ].…”

Visible to Near‐Infrared Persistent Luminescence and Mechanoluminescence from Pr3+‐Doped LiGa5O8 for Energy Storage and Bioimaging

“…Biological tissue penetration experiments were also carried out to display the potential of PersL in bioimaging . The pork was chosen to simulate tissues, and 2 mm thick skin, fat, and lean plate samples were designed.…”

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

“…The classical metal nanomaterials have generated great interest because of their excellent photothermal conversion performance in anticancer therapies. It has been reported that bismuth-doped BG scaffolds displayed high photothermal conversion efficiency to induce hyperthermia for osteosarcoma treatment 60 . Meanwhile, multiple kinds of metal oxide nanoparticles have been used as photoabsorbers to kill cancer cells.…”