Multi-Functional 3,4-Dihydroquinazoline Derivative as T-Type Calcium Channel Blocker: Pharmacokinetics and Anti-Tremor Activity

Three-component one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in 2,2,2-trifluoroethanol

“…In a continuation of our work on the application of fluorinated alcohols in several organic transformations [17][18][19][20][21][22], we have developed an efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives under reflux conditions in 2,2,2-trifluoroethanol without the use of a catalyst or any other additives. 2,3dihydroquinazolinones are very important compounds partially because of their pharmacological properties which include wide applications in medicinal chemistry; notable among them are antifertility, antibacterial, antitumor, antitremor, antifungle, and mono-amine oxidize inhibition [23][24][25][26]. In addition, 2,3-dihydroquinazolinone derivatives have recently been evaluated as antagonists of various biological receptors, such as 5-HT 5A related diseases [27], calcitonin gene-related peptide [28], and vasopressin V3 receptors [29].…”