Multi-elemental characterization of soft biological tissues by inductively coupled plasma–sector field mass spectrometry

Determination of cadmium, cobalt, copper, iron, manganese, and zinc in thyroid glands of patients with diagnosed nodular goitre using ion chromatography

“…Despite multi elemental capability and high sensitivity, which make ICP-MS an attractive technique for the analysis of biological samples, several types of non-spectral and spectral interferences can complicate the analysis of samples with complex matrices. Engström et al described the potential of inductively coupled plasma-sector field mass spectrometry (ICP-SFMS) in the determination of 68 elements in various animal tissues [16]. Inductively coupled plasma atomic emission spectrometry (ICP-AES) [17], neutron activation analysis (NAA) [18], X-ray fluorescence spectrometry (XRF) [19], total-reflection X-ray fluorescence (TRXRF) [20], particleinduced X-ray emission (PIXE) [21] are the other most commonly used techniques in trace analysis of human tissues and body fluids.…”

Trace elements in cerebrospinal fluid and blood from patients with a rare progressive central and peripheral demyelinating disease

“…Through common disease mechanisms, the results from this study may also be relevant for the pathogenesis of other demyelinating disorders such as multiple sclerosis (MS). Using HR-ICP-MS (high resolution inductively coupled plasma mass spectrometry) [13], we determined 31 elements in CSF, blood plasma and whole blood from these patients, MS patients and a control group. We found substantially raised Cu and Fe levels in CSF of Skogholt patients, which might suggest a role of these metals in the pathogenesis of the disease.…”

Uptake and Accumulation of Anthropogenic Os in Free-Living Bank Voles (Myodes glareolus)

“…We dissected the remaining 17 specimens and V, Cr, Ni, Mo, and Os concentrations in separate tissues were measured by ICP-SFMS equipped with a solution nebulization introduction system following acid digestion (a mixture of nitric and hydrofluoric acids) in Teflon vessels in accordance with a procedure described in detail previously (Engström et al 2004). Due to limited sample size, relatively poor sensitivity (a result of the high ionization potential of analyte and inefficient sample utilization by the solution nebulization introduction system), and low content in the samples, these measurements were unable to provide Os isotopic information for individual organs/tissues.…”

“…For determination of V, Cr, Ni, and Mo accuracy we evaluated the certified reference material SRM 8414 Bovine Muscle Powder (National Institute of Standards and Technology. Gaithersburg, MD, USA) (Engström et al 2004). To the best of our knowledge, there is no matrix matched reference material with certified Os concentration and/or isotope composition commercially available.…”