Multi-element substituted hydroxyapatites: synthesis, structural characteristics and evaluation of their bioactivity, cell viability, and antibacterial activity

Rajendran, Abinaya; Balakrishnan, Subha; Ravichandran, K.; Nellaiappan, Sankara Narayanan T. S.

doi:10.1007/s10971-018-4634-x

Cited by 11 publications

(11 citation statements)

References 70 publications

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“…The agglomeration observed in the morphology is mainly ascribed to the Ostwald ripening. Further, the analysis revealed the presence of spherical sized grains with their dominant distribution elevated from the boundary layer 23 . The comparative morphological analysis of the four different samples indicated a good uniformity despite the varied level of La 3+ and Pr 3+ co‐substitutions at the HAP structure.…”

Section: Resultsmentioning

confidence: 91%

Apatite matrix substituted with biologically essential rare earth elements as an artificial hard tissue substitute: Systematic physicochemical and biological evaluation

Chandran

2020

J Biomedical Materials Res

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Hydroxyapatite (HAP) forms the main inorganic component of natural bone and hence has been widely use in implant applications. Ionic substitutions in apatite also gains enormous interest during the recent years due to the crucial role played by these elements in the biological process. In this context, the least investigated elements namely lanthanum (La3+) and praseodymium (Pr3+) have been selected as a potential substitutions in apatite. The results from the analytical techniques confirm the phase purity of the HAP and its ability holds the substitutions at its lattice. Morphological analysis unveils the presence of agglomerated spheroids notwithstanding the ion concentration of substituents. EDX spectra affirm the presence of La and Pr alongside the determined Ca/P atomic ratio of 1.67. La3+ and Pr3+ presence envisaged the good antibacterial efficiency against the tested microbes and further demonstrated the biocompatibility nature from the cytotoxicity analysis.

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Section: Resultsmentioning

confidence: 91%

Apatite matrix substituted with biologically essential rare earth elements as an artificial hard tissue substitute: Systematic physicochemical and biological evaluation

Chandran

2020

J Biomedical Materials Res

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“…In this respect, we acknowledge the recent contributions focused to ascertain both synergic ion doping combinations and their optimal concentration. So far, HA has been co-substituted with: Ag/Bi [523], Ag/F [524], Ag/Mg [525,526], Ag/Si [527], Ag/Sr [528,529], Ag/Zn [281,530], Ce/Fe [381], Ce/Eu [531], Sr/Ce [344,532], Sr/Cu [533], Sr/Zn [534,535], Zn/Cu [533,536], Zn/F [78], Zn/Fe [537], La/Ag [405], La/Cu [538], Sm/Gd [354], Tb/Gd [539], Ce/Zr/F [540], Ag/Ti/F [541], Mg/Zn/Co [542], Sr/Co/F [543], Ag/Cu/Zn/F [544], or Ag/Cu/Zn/Ti [545].…”

Section: Future Perspectives: Co-substituted Hydroxyapatite Biocermentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

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High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

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“…Investigated compositions include

{CO}_{3}^{2 -}

/F − /Cl − /Na + /Mg 2+ /K + , Mg 2+ /Ni + /

{SiO}_{4}^{4 -}

, Sb 3+ /Mn 2+ /F − /Cl − , Sr 2+ /Mg 2+ /Mn 2+ , Mg 2+ /Zn 2+ /Co 2+ , Zn 2+ /Ag + /Au 2+ , Ag + /Zn 2+ /Mg 2+ /Sr 2+ , and

{CO}_{3}^{2 -}

/F − /Na + /Mg 2+ co‐substitutions.…”

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

“…Rajendran et al synthesised Mg 2+ /Zn 2+ /Co 2+ tri‐substituted hydroxyapatites (MgZnCo‐HAp) by sol gel method. They demonstrated that the simultaneous incorporation of Mg 2+ , Zn 2+ , and Co 2+ does not significantly alter the powder morphology, whereas it strongly influences HAp structural characteristics.…”

Section: Multi‐substituted Hydroxyapatite Powders and Coatingsmentioning

confidence: 99%

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Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Cacciotti

2019

Int J Applied Ceramic Tech

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The biological apatite, whose the bone and teeth mineral phases are composed, remarkably differs from stoichiometric hydroxyapatite (HAp, Ca10(PO4)6(OH)2, Ca/P = 1.667). Indeed, it consists in carbonated Ca‐deficient (Ca/P < 1.667) apatite, characterised by the presence of several vicarious ions, either incorporated within the apatite lattice or just adsorbed on the crystal surface, including anionic (eg, F−, Cl−, SiO44- and CO3=) and/or cationic substitutions (eg, Na+, Mg2+, K+, Sr2+, Zn2+, Ba2+, Al3+). For this reason, recently, a continuous and rising attention has been devoted to the ionic substitutions within the hydroxyapatite lattice in order to resemble the chemical composition of the bone mineral component and to improve its chemical, physical and mostly biological properties, for applications in biomedical sector, particularly in dentistry, orthopaedics and bone tissue engineering. The present manuscript provides a complete overview about the bi‐substituted hydroxyapatites in form of powders and coatings, in order to evidence the effect of the co‐doping with different vicarious ions within HAp lattice on its physicochemical properties, such as microstructure, morphology, thermal stability, solubility, thermal decomposition, dissolution, grain size, mechanical strength, degradation kinetics, corrosion resistance, and biological responsiveness, in terms of in vitro bioactivity, cytotoxicity and antibacterial action.

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Multi-element substituted hydroxyapatites: synthesis, structural characteristics and evaluation of their bioactivity, cell viability, and antibacterial activity

Cited by 11 publications

References 70 publications

Apatite matrix substituted with biologically essential rare earth elements as an artificial hard tissue substitute: Systematic physicochemical and biological evaluation

Apatite matrix substituted with biologically essential rare earth elements as an artificial hard tissue substitute: Systematic physicochemical and biological evaluation

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

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