Multi-drug resistant Mycobacterium tuberculosis &amp; oxidative stress complexity: Emerging need for novel drug delivery approaches

Dua, Kamal; Rapalli, Vamshi Krishna; Shukla, Shakti D.; Singhvi, Gautam; Shastri, Madhur D.; Chellappan, Dinesh Kumar; Satija, Saurabh; Mehta, Meenu; Gulati, Monica; Pinto, Terezinha de Jesus Andreoli; Gupta, Gaurav; Hansbro, Philip M.

doi:10.1016/j.biopha.2018.08.101

Cited by 70 publications

(39 citation statements)

References 115 publications

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“…Previous studies have reported that oxidants and LPO are negatively correlated with antioxidants. Reduced levels of cellular antioxidants and accelerated free radical production can be critical factors in arthritis . Quiñonez‐Flores et al reported the crucial role of oxidative stress and antioxidants in arthritis.…”

Section: Discussionmentioning

confidence: 99%

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Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

Cui

Sreeharsha

et al. 2020

IUBMB Life

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Background Rheumatoid arthritis (RA) is associated with joint damage. Effectiveness of embelin has been established in a wide variety of inflammatory disorders, but its utility as a therapeutic agent is limited by its poor absorption, rapid metabolism, and fast systemic elimination. To apprehend these limitations, we propose to use highly bioavailable embelin‐loaded chitosan nanoparticles (CS‐embelin NPs) for the treatment of RA. Methods The rats were made arthritic using a subcutaneous injection with 0.1 ml complete Freund's adjuvant (CFA) into the footpad of the left hind paw. CS‐embelin NPs (25 and 50 mg/kg) was administered from day 15 to day 28 after adjuvant injection. After the experimental period, the animals were sacrificed and various biochemical markers were assessed. Results Arthritic score and paw swelling were significantly reduced after treatment with CS‐embelin NPs. Arthritis‐induced rats showed a significant increase in malondialdehyde (MDA) and nitric oxide (NO) with a concomitant reduction of antioxidants in the paw tissue. CS‐embelin NPs (25 and 50 mg/kg) reduced MDA and NO levels and restored antioxidant levels to normalcy by mitigating oxidative stress. The arthritic rats exhibited elevated tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and interleukin‐1beta (IL‐1β) serum concentrations, upregulated TNF‐ α and IL–6 protein levels and upregulated nuclear factor‐kB (NF‐kB) mRNA expression in paw tissues. Treatment with CS‐embelin NPs (25 and 50 mg/kg) significantly reduced serum levels and down‐regulated inflammatory markers to normalcy, dose‐dependently. Conclusion The results suggest that CS‐embelin NPs displayed a protective effect against adjuvant‐induced arthritis in rats mediated through antioxidant and anti‐inflammatory effects.

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Section: Discussionmentioning

confidence: 99%

“…Reduced levels of cellular antioxidants and accelerated free radical production can be critical factors in arthritis. 39,40 Quiñonez-Flores et al reported the crucial role of oxidative stress and antioxidants in arthritis. GSH and SOD levels were drastically reduced in arthritis-induced experimental rats.…”

Section: Discussionmentioning

confidence: 99%

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

Cui

Sreeharsha

et al. 2020

IUBMB Life

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“…Respiratory diseases like lung cancer, inflammatory diseases with chronic obstructive pulmonary disease (COPD), asthma, respiratory infections and pulmonary fibrosis are some of the major causes of death globally [1][2][3]. Currently available treatment options for these diseases have limited efficacy [4].…”

Section: Introductionmentioning

confidence: 99%

“…• PCR (polymerase chain reaction) primer • RNA, siRNA and antisense studies • Melting point optimization of oligonucleotides • Molecular diagnostics • Gene therapy • Microarrays • Fluorescence in situ hybridization (FISH) • Fluorescence resonance energy transfer (FRET) [3].…”

Section: Introductionmentioning

confidence: 99%

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

Mehta

Deeksha

Tewari

et al. 2019

Chemico-Biological Interactions

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107

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“…Despite the huge burden of major respiratory disease, there is a lack of effective treatments that could limit the disease onset and/or disease progression (Dua, Chellappan, et al, ; Dua, Gupta, Chellappan, Shukla, & Hansbro, ; Dua, Rapalli, et al, ; Dua, Shukla, de Jesus Andreoli Pinto, & Hansbro, ; Rapalli et al, ). Thus, extensive research into potentially novel therapeutics is urgently required.…”

Section: Introductionmentioning

confidence: 99%

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

Dua

Wadhwa

Singhvi

et al. 2019

Drug Development Research

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104

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Lung diseases are the leading cause of mortality worldwide. The currently available therapies are not sufficient, leading to the urgent need for new therapies with sustained anti‐inflammatory effects. Small/short or silencing interfering RNA (siRNA) has potential therapeutic implications through post‐transcriptional downregulation of the target gene expression. siRNA is essential in gene regulation, so is more favorable over other gene therapies due to its small size, high specificity, potency, and no or low immune response. In chronic respiratory diseases, local and targeted delivery of siRNA is achieved via inhalation. The effectual delivery can be attained by the generation of aerosols via inhalers and nebulizers, which overcomes anatomical barriers, alveolar macrophage clearance and mucociliary clearance. In this review, we discuss the different siRNA nanocarrier systems for chronic respiratory diseases, for safe and effective delivery. siRNA mediated pro‐inflammatory gene or miRNA targeting approach can be a useful approach in combating chronic respiratory inflammatory conditions and thus providing sustained drug delivery, reduced therapeutic dose, and improved patient compliance. This review will be of high relevance to the formulation, biological and translational scientists working in the area of respiratory diseases.

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Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches

Cited by 70 publications

References 115 publications

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

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