Multi-detector Row CT: Effect of Iodine Dose Reduction on Hepatic and Vascular Enhancement

doi:10.1055/s-2004-813018

Cited by 17 publications

(1 citation statement)

References 14 publications

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“…Surprisingly, very few recommendations about the minimum iodine flux and minimum total amount of iodine necessary for abdominal CT angiography of sufficient image quality and diagnostic confidence have been published to date [13]. Roos and co-authors have shown that an iodine concentration of at least 300 mgI/ml should be recommended [28]. Ho et al have shown that the volume of contrast medium can be reduced to a mean quantity of 107 ml (300 mgI/ml) in abdominal aortic CT angiography for aortic aneurysms without a significant decrease in aortic attenuation [29].…”

Section: Discussionmentioning

confidence: 99%

64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial

Loewe

Becker²,

Berletti³

et al. 2009

Eur Radiol

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PurposeThe purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries.MethodsIRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol.ResultsThe ability to reach a diagnosis was “satisfactory” to “totally satisfactory” in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being “good” to “excellent” in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.ConclusionThis study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.

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Section: Discussionmentioning

confidence: 99%