64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial

Abstract

PurposeThe purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries.MethodsIRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol.ResultsThe ability to reach a diagnosis was “satisfactory” to “totally satisfactory” in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being “good” to “excellent” in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.ConclusionThis study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.

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“…[1][2][3][4] One important aspect of abdominal CTA is the vasculature-to-background contrast. This iodine-based contrast can be increased when applying low-tube-voltages.…”

Comparison of Noninvasive Imaging Modalities for Stenosis Grading in Mesenteric Arteries

“…Corresponding to Bhatti et al [12] who found CTA superior to MRA in renal arteries, our data indicate the superiority of CTA over MRA and duplex US in the two mesenteric arteries. Loewe et al refer to the outstanding role of CTA as a safe, robust and reproducible modality for diagnosing diseased abdominal arteries, and they rated the broad majority of their evaluated abdominal arteries as of good or excellent image quality [13]. We found CTA to offer the best image quality among the four assessed modalities, rated 4.4 as also good to excellent imaging.…”

Objective evaluation of acute adverse events and image quality of gadolinium-based contrast agents (gadobutrol and gadobenate dimeglumine) by blinded evaluation. Pilot study

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