Multi‐channel wireless mapping of gastrointestinal serosal slow wave propagation

Abstract

Background High-resolution (HR) extracellular mapping allows accurate profiling of normal and dysrhythmic slow wave patterns. A current limitation is that cables traverse the abdominal wall or a natural orifice, risking discomfort, dislodgement or infection. Wireless approaches offer advantages, but a multi-channel system is required, capable of recording slow waves and mapping propagation with high fidelity. Methods A novel multi-channel (n=7) wireless mapping system was developed and compared to a wired commercial system. Slow wave signals were recorded from the porcine gastric and intestinal serosa in-vivo. Signals were simultaneously acquired using both systems, and were filtered and processed to map activation wavefronts. For validation, the frequency and amplitude of detected events were compared, together with the speed and direction of mapped wavefronts. Key Results The wireless device achieved comparable signal quality to the reference device, and slow wave frequencies were identical. Amplitudes of the acquired gastric and intestinal slow wave signals were consistent between the devices. During normal propagation, spatiotemporal mapping remained accurate in the wireless system, however, during ectopic dysrhythmic pacemaking, the lower sampling resolution of the wireless device led to reduced accuracy in spatiotemporal mapping. Conclusions and Inferences A novel multichannel wireless device is presented for mapping slow wave activity. The device achieved high quality signals, and has the potential to facilitate chronic monitoring studies and clinical translation of spatiotemporal mapping. The current implementation may be applied to detect normal patterns and dysrhythmia onset, but HR mapping with finely spaced arrays currently remains necessary to accurately define dysrhythmic patterns.

A wireless system for gastric slow wave acquisition and gastric electrical stimulation

“…The analog conditioning board and its frequency response were validated in previous publications [4]- [5]. In this paper, we further examined the front-end and the stimulation capabilities.…”

“…We advocate wireless technology to overcome these barriers. In preliminary work, we developed and evaluated two novel systems that can record slow waves from 4 or 7 channels in real-time [4]- [5]. No other existing wireless system can acquire signals from multiple channels for a longer period.…”

A novel retractable laparoscopic device for mapping gastrointestinal slow wave propagation patterns

“…A promising recent development is the design of a wireless implantable recording device that transmits slow wave recordings directly to analytical equipment, without the need for cables [45]. This system has the advantage that it may potentially be implanted allowing longer-term longitudinal studies without the increased potential for infection that wires traversing the abdomen may cause.…”

Time-Delay Mapping of High-Resolution Gastric Slow-Wave Activity

“…In recent years, real-time analysis of electrophysiological data in high spatiotemporal resolution has achieved striking clinical success, guiding diagnosis and interventional therapies in cardiac and neural fields [1–4]. Similar advances of high-resolution (HR) bio-electrical monitoring have also emerged in the gastrointestinal (GI) field, to advance the basic understanding of slow waves and to develop diagnostic and therapeutics for functional motility disorders [5–7]. …”