Multi‐channel orbicularis oculi stimulation to restore eye‐blink function in facial paralysis

Somia, F.R.C.S Naveen N.; Zonnevijlle, Erik D. H.; Stremel, Richard W.; Maldonado, Claudio; Gossman, M. Douglas; Barker, John H.

doi:10.1002/micr.1050

Cited by 27 publications

(25 citation statements)

References 66 publications

(38 reference statements)

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“…A prior study observed that rabbits initially flinched in response to orbicularis oculi stimulation, but signs of pain diminished over time (Otto, 1997). There is evidence that FES paradigms including interferential stimulation (McDonnall et al, 2009) and low-intensity multichannel stimulation (Somia et al, 2001) render facial muscle stimulation functional but not painful. Finally, facial FES has been achieved in humans reporting only mild pain (McDonnall et al, 2009; Frigerio et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…The effectiveness of FES in activating paralyzed facial muscles, in particular the orbicularis oculi to restore eye blink, has been demonstrated in rabbits and dogs (Rothstein and Berlinger, 1986; Salerno et al, 1991; Otto, 1997; Somia et al, 2001; Sachs et al, 2007; Jie et al, 2016). Since many facial movements including eye blink are symmetric, a natural closed-loop FES control signal in unilateral facial paralysis can be derived from the intact side of the face.…”

Section: Introductionmentioning

confidence: 99%

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A Rodent Model of Dynamic Facial Reanimation Using Functional Electrical Stimulation

et al. 2017

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Facial paralysis can be a devastating condition, causing disfiguring facial droop, slurred speech, eye dryness, scarring and blindness. This study investigated the utility of closed-loop functional electric stimulation (FES) for reanimating paralyzed facial muscles in a quantitative rodent model. The right buccal and marginal mandibular branches of the rat facial nerve were transected for selective, unilateral paralysis of whisker muscles. Microwire electrodes were implanted bilaterally into the facial musculature for FES and electromyographic (EMG) recording. With the rats awake and head-fixed, whisker trajectories were tracked bilaterally with optical micrometers. First, the relationship between EMG and volitional whisker movement was quantified on the intact side of the face. Second, the effect of FES on whisker trajectories was quantified on the paralyzed side. Third, closed-loop experiments were performed in which the EMG signal on the intact side triggered FES on the paralyzed side to restore symmetric whisking. The results demonstrate a novel in vivo platform for developing control strategies for neuromuscular facial prostheses.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Rodent Model of Dynamic Facial Reanimation Using Functional Electrical Stimulation

et al. 2017

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“…Good results have also been reported in working with spinal injuries [14][15][16], facial nerve paralysis [17], and quadriplegia [2], as well as in the treatment of conditions such as child epilepsy [18][19] and Parkinson's disease [20]. Further, while not yet formally reported in academic papers, attempts are also being made to use stimulating electrode implants to achieve lasting recovery in cases of nerve damage.…”

Section: Application To Medical Treatmentmentioning

confidence: 99%

Analysis of Patterned Neuronal Impulses and Function of Neuregulin

Ozaki¹

2002

Neurosignals

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Compared to other cells, except neural cells, the biggest property of neural cells is to have a particular electrical activity in each cell itself. The activity that shows a specific pattern will carry different information as a history of each neural cell. At present, we have examined the roles of neural impulses and revealed that a synaptic plasticity can be controlled by different patterned neural acitivites, such as different frequencies or oscillation patterns. Even though neural cells have similar genetic backgrounds, different environments give cells different neural activities and finally different characters of cells. Current studies have revealed that a particular pattern of neural activity, e.g. frequency, could be effective in some diseases. In response to environmental changes occurring throughout development and adult life, the brain reorganizes itself by adjusting the pattern of activity. In some cases, a particular pattern of neural acitivity decides the neural fate and should be able to control brain function even in higher functions. In the future, in order to understand the role of activity patterns and mechanisms of fundamental information processing in the brain, it will be necessary that the meaning of patterns is explained from molecular, biological and morphological perspectives, i.e., not only with metaphysical ‘phenomena’, but also at a physical ‘material’ level.

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“…Biological tissues and body fluids also respond to electrode electrolysis, corrosion and electrical characteristics in different ways. 5,6 These differences must be controlled within a certain range to guarantee proper function of the implanted materials in the facial nerve system and prevent harm to biological tissue. Implant studies are critical for clarifying and addressing these effects and differences.…”

Section: Introductionmentioning

confidence: 99%

Comparative studies on the implantation of nano platinum black and pure platinum electrodes in the rabbit orbicularis oculi muscle

Zhang

Cheng

et al. 2014

J. Laryngol. Otol.

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Objective: To study the interactive influence of implanted nano platinum black electrodes (as compared with pure platinum electrodes) on rabbit orbicularis oculi muscle morphology and function.Methods: The influence of the two types of electrode on the orbicularis oculi muscle was monitored in a rabbit model of facial paralysis. Biological electric current and exciting current were administered to biological tissue, and morphological and functional changes were identified. Changes in orbicularis oculi muscle contraction, electrode configuration and performance associated with long-term electrical stimulation were observed over 28 days of implantation.Results: The nano platinum black electrode was superior to the pure platinum electrode in the following aspects: morphology and functionality, electrical excitation function of the orbicularis oculi muscle (as assessed by electromyography), muscle contraction function and biological tissue changes. Furthermore, the nano platinum black electrode features had good stability.Conclusion: Microelectrode surface modification with nano platinum black can effectively increase the microelectrode surface area and improve electrode performance, and is associated with good tissue compatibility.

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Multi‐channel orbicularis oculi stimulation to restore eye‐blink function in facial paralysis

Cited by 27 publications

References 66 publications

A Rodent Model of Dynamic Facial Reanimation Using Functional Electrical Stimulation

A Rodent Model of Dynamic Facial Reanimation Using Functional Electrical Stimulation

Analysis of Patterned Neuronal Impulses and Function of Neuregulin

Comparative studies on the implantation of nano platinum black and pure platinum electrodes in the rabbit orbicularis oculi muscle

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