Multi-center evaluation of oxidation reduction potential assay in the infertile male

Agarwal, Ashok; Chandrakumar, R.; Arafa, Mohamed; Elbardisi, Haitham; Okada, Hiroshi; Suzuki, Kazuyoshi; Homa, Sheryl T.; Killeen, Aideen P.; Balaban, Başak; Ayaz, Ahmet; Saleh, Ramadan; Armağan, Abdullah; Roychoudhury, Shubhadeep; Sikka, Sanjay

doi:10.1016/j.fertnstert.2017.07.939

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was also a negative correlation with ORP and these parameters (p<0.05). Lastly, Agarwal et al [ 68 ] conducted a multicenter study at 9 institutions around the world with 2010 recruited participants. An ORP cutoff value of 1.34 mV/10 6 sperm/mL was able to identify samples with abnormal semen parameters with 58% sensitivity, 85% specificity, 96% PPV, 42% NPV, and AUC=0.757.…”

Section: Future Direction Of Oxidation-reduction Potential Clinical Umentioning

confidence: 99%

Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility

Agarwal

Bui

2017

Investig Clin Urol

View full text Add to dashboard Cite

Male infertility affects men worldwide. Oxidative stress (OS), characterized by an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, is one of the major causes of male infertility. OS causes damage at the molecular level, which impairs lipids, proteins, and DNA. The cyclic cascade of redox reactions weakens sperm function which leads to poor semen parameters and eventual sterility. There is a need for advanced diagnostic tests that can quickly and accurately detect OS. Most commonly used assays can only measure single constituents of OS. However, the MiOXSYS System introduces a new strategy to detect OS by measuring the oxidation-reduction potential (ORP)--a direct evaluation of the redox balance between ROS and antioxidants. The MiOXSYS System has shown promise as a diagnostic tool in the evaluation of male infertility. This review explores the concept of ORP, details the principle of the MiOXSYS System, and summarizes the findings in clinical studies that support ORP measurement in semen.

show abstract

Section: Future Direction Of Oxidation-reduction Potential Clinical Umentioning

confidence: 99%

Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility

Agarwal

Bui

2017

Investig Clin Urol

View full text Add to dashboard Cite

show abstract

“…Measuring ORP, or redox potential, is the most recent advance in identifying a single direct marker of male factor infertility. ORP provides a snapshot of the oxidant-to-antioxidant relationship and yields insight into the redox equilibrium and the state of OS in each sample [ 55 56 57 ]. ORP levels in whole blood have been shown to increase due to trauma [ 58 59 ], intense exercise [ 60 ], and organ dysfunction [ 61 ].…”

Section: A Potential Solution—measuring Oxidation-reduction Potentialmentioning

confidence: 99%

“…ORP levels in whole blood have been shown to increase due to trauma [ 58 59 ], intense exercise [ 60 ], and organ dysfunction [ 61 ]. In cases of male infertility, ORP levels have also been found to be elevated [ 55 56 57 ]. ORP has been utilized in the clinical andrology setting as a reliable marker of OS in human semen samples [ 62 ].…”

Section: A Potential Solution—measuring Oxidation-reduction Potentialmentioning

confidence: 99%

“…In order to improve the ease of use, standardized laboratory protocols and consistent device software upgrades have been implemented. MiOXSYS produces results based on the patients' physiological balance of oxidants vs. antioxidants, represented by ORP, which has been shown to be both stable and reproducible [ 55 56 57 ]. Due to these qualities, MiOXSYS has the potential to mitigate the problems of unreliability inherent in manual SA as well as the issues of extensive training, cost, and oversight associated with advanced SA tests.…”

Section: A Potential Solution—measuring Oxidation-reduction Potentialmentioning

confidence: 99%

See 1 more Smart Citation

A Novel Approach to Improving the Reliability of Manual Semen Analysis: A Paradigm Shift in the Workup of Infertile Men

Douglas

Parekh

Kahn

et al. 2021

World J Mens Health

View full text Add to dashboard Cite

Conventional semen analysis (SA) is an essential component of the male infertility workup, but requires laboratories to rigorously train and monitor technicians as well as regularly perform quality assurance assessments. Without such measures there is room for error and, consequently, unreliable results. Furthermore, clinicians often rely heavily on SA results when making diagnostic and treatment decisions, however conventional SA is only a surrogate marker of male fecundity and does not guarantee fertility. Considering these challenges, the last several decades have seen the development of many advances in SA methodology, including tests for sperm DNA fragmentation, acrosome reaction, and capacitation. While these new diagnostic tests have improved the scope of information available to clinicians, they are expensive, time-consuming, and require specialized training. The latest advance in laboratory diagnostics is the measurement of seminal oxidation-reduction potential (ORP). The measurement of ORP in an easy, reproducible manner using a new tool called the Male Infertility Oxidative Stress System (MiOXSYS) has demonstrated ORP's potential as a feasible adjunct test to conventional SA. Additionally, the measurement of ORP by this device has been shown to be predictive of both poor semen quality and male infertility. Assessing ORP is a novel approach to both validating manual SA results and identifying patients who may benefit from treatment of male oxidative stress infertility.

show abstract

Seminal Oxidation-Reduction Potential

Rana

Agarwal

2020

Male Infertility

View full text Add to dashboard Cite

Multi-center evaluation of oxidation reduction potential assay in the infertile male

Cited by 3 publications

References 0 publications

Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility

Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility

A Novel Approach to Improving the Reliability of Manual Semen Analysis: A Paradigm Shift in the Workup of Infertile Men

Seminal Oxidation-Reduction Potential

Contact Info

Product

Resources

About