Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility

Agarwal, Ashok; Bui, Albert

doi:10.4111/icu.2017.58.6.385

Cited by 74 publications

(88 citation statements)

References 84 publications

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“…Whilst it is still disputed how all these components regulate sperm function, the spatial control and temporal control of OXPHOS suggest that mitochondrial activity is important. It is therefore not surprising that oxidative stressas a result of excessive reactive oxygen species (ROS) mainly produced by mitochondrial OXPHOSis one of the best molecular markers for male subfertility [72][73][74]. Whilst prolonged oxidative stress is associated with infertility and indicates exhausted or damaged spermatozoa, OXPHOS activity kept under control at the right time and place indicates healthy spermatozoa.…”

Section: Dynamic Changes Of Sperm Sncrna During Spermatogenesismentioning

confidence: 99%

Male reproductive health and intergenerational metabolic responses from a small RNA perspective

Nätt

Öst

2020

J Intern Med

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The world has recently experienced a decline in male reproductive (e.g. sperm counts and motility) and metabolic (e.g. obesity and diabetes) health. Accumulated evidence from animal models also shows that the metabolic health of the father may influence the metabolic health in his offspring. Vectors for such paternal intergenerational metabolic responses (IGMRs) involve small noncoding RNAs (sncRNAs) that often increase in spermatozoa during the last days of maturation in the epididymis. We and others have shown that the metabolic state – depending on factors such as diet, obesity and physical exercise – may affect sperm quality and sperm sncRNA. Together, this suggests that there are overlapping aetiologies between the male metabolic syndrome, male factor infertility and intergenerational responses. In this review, we present a theoretical framework for an overlap of these aetiologies by exploring the advances in our understanding of the roles of sncRNA in spermatogenesis and offspring development. A special focus will lie on novel findings about tRNA‐derived small RNA (tsRNA), rRNA‐derived small RNA (rsRNA) and small mitochondrial RNA (mitoRNA), and their emerging roles in intergenerational metabolic and reproductive health.

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Section: Dynamic Changes Of Sperm Sncrna During Spermatogenesismentioning

confidence: 99%

Male reproductive health and intergenerational metabolic responses from a small RNA perspective

Nätt

Öst

2020

J Intern Med

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“…In the human body, antioxidant systems are present in order to neutralize free radicals [18]. An imbalance between free radical production and the antioxidant capacity causes oxidative stress (OS), which affects the structure, function, and motility of spermatozoa, leading to male infertility [19,20].…”

Section: Introductionmentioning

confidence: 99%

The effect of vitamin C on the gene expression profile of sperm protamines in the male partners of couples with recurrent pregnancy loss: A randomized clinical trial

Hamidian

Talebi

Fesahat

et al. 2020

Clin Exp Reprod Med

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Objective: Since sperm abnormalities are known to be a major reason for recurrent pregnancy loss (RPL), any defects in DNA structure and chromatin condensation can place embryos at risk in the early stage of development and implantation. As antioxidants such as vitamin C may play a protective role against the destruction of protamine genes in sperm chromatin, this study was conducted to evaluate the effects of vitamin C on chromatin and the expression of protamine genes in the male partners of couples with RPL. Methods: Twenty male partners of couples with RPL were selected as the intervention group and received vitamin C supplementation (250 mg daily for 3 months). Healthy fertile men (n = 20) were included as controls. Sperm chromatin, DNA integrity, and the expression levels of protamine genes were evaluated before and after treatment. Results: Significant differences were found in sperm morphology, protamine deficiency, and apoptosis between the two groups and before and after vitamin C administration. A significant change was found in mRNA levels of PRM1, PRM2, and the PRM1/PRM2 ratio after treatment. Conclusion: Daily oral administration of vitamin C may improve human sperm parameters and DNA integrity by increasing protamine gene expression levels in the male partners of couples with RPL. The beneficial effects of vitamin C supplementation as an antioxidant for the male partners of couples with RPL could lead to improved pregnancy outcomes in these cases. This is an Open Access article distributed under the terms of the Creative Commons AttributionNon-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. www.eCERM.org S Hamidian et al. The effect of vitamin C on sperm gene expression

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“…Infertility produces psychological stress as a couple fails achieve the expected goal of reproduction, causing disappointment and frustration that is attributed to generalized increased oxidative stress levels [ 5 ]. Oxidative stress is a well-known causative factor involved in the etiology of male infertility [ 6 , 7 ]. Oxidative stress arises when reactive oxygen species (ROS) or free radical production overwhelms the endogenous antioxidant defense of the male reproductive tract [ 1 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Ameliorating Effect of Berberine‐Rich Fraction against Gossypol‐Induced Testicular Inflammation and Oxidative Stress

Saleh

Attia

Ghareeb

2018

Oxidative Medicine and Cellular Longevity

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This study was aimed at evaluating the efficacy of berberine-rich fraction (BF) as a protective and/or a therapeutic agent against inflammation and oxidative stress during male infertility. Sexually mature Sprague-Dawley male rats were divided into five groups treated with either corn oil, BF (100 mg/kg BW, orally, daily for 30 days), gossypol acetate (5 mg/kg BW, i.p.) eight times for 16 days, BF alone for 14 days then coadministered with gossypol acetate for the next 16 days (protected group), or gossypol acetate for 16 days then treated with BF for 30 days (treated group). All animals completed the experimental period (46 days) without obtaining any treatments in the gap period. Sperm parameters, oxidative index, and inflammatory markers were measured. Gossypol injection significantly decreased the semen quality and testosterone level that resulted from the elevation of testicular reactive oxygen and nitrogen species (TBARS and NO), TNF-α, TNF-α-converting enzyme, and interleukins (IL-1β, IL-6, and IL-18) by 230, 180, 12.5, 97.9, and 300%, respectively, while interleukin-12 and tissue inhibitors of metalloproteinases-3 were significantly decreased by 59 and 66%, respectively. BF (protected and treated groups) significantly improved the semen quality, oxidative stress, and inflammation associated with male infertility. It is suitable to use more advanced studies to validate these findings.

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Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility

Cited by 74 publications

References 84 publications

Male reproductive health and intergenerational metabolic responses from a small RNA perspective

Male reproductive health and intergenerational metabolic responses from a small RNA perspective

The effect of vitamin C on the gene expression profile of sperm protamines in the male partners of couples with recurrent pregnancy loss: A randomized clinical trial

The Ameliorating Effect of Berberine‐Rich Fraction against Gossypol‐Induced Testicular Inflammation and Oxidative Stress

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