Multi-biomarker responses to estuarine habitat contamination in three fish species: Dicentrarchus labrax, Solea senegalensis and Pomatoschistus microps

Fonseca, Vanessa F.; França, Susana; Serafim, A.; Company, R.; Lopes, B.; Bebianno, Maria João; Cabral, Henrique N.

doi:10.1016/j.aquatox.2011.01.018

Cited by 90 publications

(60 citation statements)

References 58 publications

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“…Study by Sevcikova et al [71], on the effect of metals on MT content in fish from Skalka and Želivka reservoirs, indicated that MT did not seem to be induced by high metal contamination. Low MT levels was also observed in polluted sites characterized by metals contamination, petroleum/crude hydrocarbon inputs and combustion PAH sources as reported by Fonseca et al [72].…”

Section: Mt Levels In the Tissues Of Mudskipper P Schlosserisupporting

confidence: 56%

Evaluation of metallothionein content in giant mudskipper Periophthalmodon schlosseri collected from west coast of Peninsular Malaysia to assess environmental metal pollution

Buhari¹,

Ismail²

2017

JCLM

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Section: Mt Levels In the Tissues Of Mudskipper P Schlosserisupporting

confidence: 56%

Evaluation of metallothionein content in giant mudskipper Periophthalmodon schlosseri collected from west coast of Peninsular Malaysia to assess environmental metal pollution

Buhari¹,

Ismail²

2017

JCLM

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“…An average twofold increase in EROD activity has been described in sole fish exposed to a moderate pollution gradient in a field situation (Fonseca et al 2011;Gonçalves et al 2014;Siscar et al 2015). Up to a fourfold increase in EROD activity was reached in S. solea exposed to a more significant PAH pollution gradient in the NW Mediterranean (Trisciani et al 2011).…”

Section: Discussionmentioning

confidence: 94%

The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system

Crespo

Solé

2016

Environ Sci Pollut Res

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Juveniles of Solea solea were sampled during the spring season in three consecutive years at a marine site by the mouth of the Ebre river. The aim was to assess if the extractive works from the toxic load upstream the river could be reflected on the health status of the fish living at the immediate sea. The biomarkers selected for the in vivo field study are commonly used as indicators of chemical exposures. They include activities of energy metabolism: lactate dehydrogenase (LDH) and citrate synthase (CS); neurotoxicity: cholinesterases (ChE); xenobiotic metabolism: cytochrome P450 (CYP)-dependent: EROD and BFCOD, carboxylesterase (CbE), glutathione S-transferase (GST) and uridine diphosphate glucuronyltransferase (UDPGT); and oxidative stress parameters such as catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GPX) as well as levels of lipid peroxidation (LPO). These biomarkers were mostly analysed in liver but also in gills and muscle depending on their particular tissue distribution and role. A complementary in vitro approach was also sought to see the capacity of common emerging contaminants (pharmaceuticals and personal care products; PPCPs) to interact with the liver microsomal detoxification system of the fish (EROD, BFCOD and CbE activities). The results indicated that in fish sampled in 2015 there was an enhancement in detoxification parameters (EROD, BFCOD and gill GR), muscular ChEs and gill CS, but a decrease in CbE activity and a marked oxidative stress situation (increased LPO and decreased CAT activity). Also, 4 out of the 10 PPCPs tested in vitro were able to interact with the CYP3A4 (BFCOD) enzymatic system while the lipid regulators simvastatin and fenofibrate inhibited CbE activity, as it occurs in higher vertebrates. The in vivo results support the use of a multibiomarker approach when assessing the disturbances due to chemical exposures, not only spatially but also over time, once the influence of other variables has been taken into consideration. The in vitro results highlight the importance of the CYP3A4 and CbE pathway in pharmaceutical metabolism, also in fish.

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“…Nevertheless, multi-metric and weight-of-evidence approaches have been considered more comprehensive for environmental quality assessment (e.g. Atkins et al, 2011;Broeg and Lehtonen, 2006;Fonseca et al, 2011a;Richardson et al, 2011). In addition to conservation purposes, quality assessment and management actions should also consider the link between ecosystem functioning and services provided and human well-being (Pinto et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Habitat quality of estuarine nursery grounds: Integrating non-biological indicators and multilevel biological responses in Solea senegalensis

Fonseca

Vasconcelos

Tanner

et al. 2015

Ecological Indicators

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Multi-biomarker responses to estuarine habitat contamination in three fish species: Dicentrarchus labrax, Solea senegalensis and Pomatoschistus microps

Cited by 90 publications

References 58 publications

Evaluation of metallothionein content in giant mudskipper Periophthalmodon schlosseri collected from west coast of Peninsular Malaysia to assess environmental metal pollution

Evaluation of metallothionein content in giant mudskipper Periophthalmodon schlosseri collected from west coast of Peninsular Malaysia to assess environmental metal pollution

The use of juvenile Solea solea as sentinel in the marine platform of the Ebre Delta: in vitro interaction of emerging contaminants with the liver detoxification system

Habitat quality of estuarine nursery grounds: Integrating non-biological indicators and multilevel biological responses in Solea senegalensis

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