To response severe disaster, such as hurricane, tsunami, or terrorists attack, multi-organization, such as government, companies, media, and public are involved. How to make these inter-or intra dependent organizations cooperate timely and accurately when they face uncertainty and stressful situation is the primary concerns. In this paper, we proposed multi-organization performance model, which introduced organizational factors, individual factors and focused on communication and collaboration among different organizations. Based on it we developed multi-agent emergency response system. This IT solution has capability to integrate drills into simulated response activities and reproduce the drills. To demonstrate how the system can be used as a powerful tool for supporting and evaluating the performance of multi-organization in disaster management and response, the test simulation is carried out using a scenario extracted from real-life emergency drills.