Mulberry leaves ameliorate obesity through enhancing brown adipose tissue activity and modulating gut microbiota

Sheng, Yao; Liu, Junyu; Zheng, Shujuan; Liang, Fei; Luo, Yunbo; Huang, Kunlun; Xu, Wentao; He, Xiaoyun

doi:10.1039/c9fo00883g

Cited by 58 publications

(43 citation statements)

References 49 publications

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“…In good accordance with these results, we also found that FML administration reversed the HFD-induced whitening of BAT and promoted its browning, as evidenced by upregulated expression of PGC-1α at the gene level and UCP1 at both the gene and protein levels. Similarly, rutin, a kind of flavonoid with abundant content in mulberry leaves (1.10 mg/g dry powder) [6], has also been shown to enhance BAT activation in both HFD-induced obese and genetically obese mice [32]. Collectively, these results indicated that FML could enhance BAT activation, and thus, promote energy to produce heat.…”

Section: Discussionmentioning

confidence: 89%

“…BAT activation can augment thermogenesis and energy expenditure, thus promoting a lean and healthy phenotype [31]. Previous studies have demonstrated that BAT activity could be enhanced by mulberry leaves, as manifested by the increased BAT/body weight ratio and upregulated mRNA expression of key genes related to BAT activation (such as UCP1, PGC-1α, and PPARγ) [6]. In good accordance with these results, we also found that FML administration reversed the HFD-induced whitening of BAT and promoted its browning, as evidenced by upregulated expression of PGC-1α at the gene level and UCP1 at both the gene and protein levels.…”

Section: Discussionmentioning

confidence: 99%

“…In this sense, the benefits of mulberry leaves reported so far include: weight loss, inhibition of adipogenesis, improvement of lipid profile, and fat depot reduction [6,7]. In addition, it has been demonstrated that the effects exerted by mulberry leaves are associated with improved brown adipose tissue (BAT) activity [6]. Mulberry leaf extract has also been demonstrated to exert antidiabetic activity in obese mice [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Mulberry leaf extract has also been demonstrated to exert antidiabetic activity in obese mice [8,9]. More interestingly, it is suggested that flavonoids from mulberry leaves (FML) may be the main functional component that exert this effect [6]. Apart from BAT activity, gut microbiota was also reported to be involved in the effects of mulberry leaves [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…More interestingly, it is suggested that flavonoids from mulberry leaves (FML) may be the main functional component that exert this effect [6]. Apart from BAT activity, gut microbiota was also reported to be involved in the effects of mulberry leaves [6,7]. It has been clearly demonstrated that gut microbiota is involved in the regulation of obesity and its related metabolic disorders [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Flavonoids from Mulberry Leaves Alleviate Lipid Dysmetabolism in High Fat Diet-Fed Mice: Involvement of Gut Microbiota

et al. 2020

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Here, we investigated the roles and mechanisms of flavonoids from mulberry leaves (FML) on lipid metabolism in high fat diet (HFD)-fed mice. ICR mice were fed either a control diet (Con) or HFD with or without FML (240 mg/kg/day) by oral gavage for six weeks. FML administration improved lipid accumulation, alleviated liver steatosis and the whitening of brown adipose tissue, and improved gut microbiota composition in HFD-fed mice. Microbiota transplantation from FML-treated mice alleviated HFD-induced lipid metabolic disorders. Moreover, FML administration restored the production of acetic acid in HFD-fed mice. Correlation analysis identified a significant correlation between the relative abundances of Bacteroidetes and the production of acetic acid, and between the production of acetic acid and the weight of selected adipose tissues. Overall, our results demonstrated that in HFD-fed mice, the lipid metabolism improvement induced by FML administration might be mediated by gut microbiota, especially Bacteroidetes-triggered acetic acid production.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Flavonoids from Mulberry Leaves Alleviate Lipid Dysmetabolism in High Fat Diet-Fed Mice: Involvement of Gut Microbiota

et al. 2020

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Flavonoids, gut microbiota, and host lipid metabolism

Zhou,

Ma,

Kang

et al. 2023

Engineering in Life Sciences

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Flavonoids are widely distributed in nature and have a variety of beneficial biological effects, including antioxidant, anti‐inflammatory, and anti‐obesity effects. All of these are related to gut microbiota, and flavonoids also serve as a bridge between the host and gut microbiota. Flavonoids are commonly used to modify the composition of the gut microbiota by promoting or inhibiting specific microbial species within the gut, as well as modifying their metabolites. In turn, the gut microbiota extensively metabolizes flavonoids. Hence, this reciprocal relationship between flavonoids and the gut microbiota may play a crucial role in maintaining the balance and functionality of the metabolism system. In this review, we mainly highlighted the biological effects of antioxidant, anti‐inflammatory and antiobesity, and discussed the interaction between flavonoids, gut microbiota and lipid metabolism, and elaborated the potential mechanisms on host lipid metabolism.

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Mulberry (Morus alba L.) leaf polysaccharide ameliorates insulin resistance‐ and adipose deposition‐associated gut microbiota and lipid metabolites in high‐fat diet‐induced obese mice

Zhao

Yao

et al. 2021

Food Science & Nutrition

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Dietary supplements are currently being used to ameliorate metabolic alterations via maintaining gut microflora balance. Mulberry leaf is known as medicine homologous food for its glucose‐ and lipid‐modulating properties. However, the effects of mulberry leaf polysaccharide (MP) on metabolic dysbiosis and gut microbiota are still poorly understood. After extraction and characterization, the beneficial effects of water‐soluble MP were evaluated in high‐fat diet‐induced obese mice. MP treatment could reduce adipose tissue, improve insulin resistance, and alleviate the pathological lesions in colon. Investigation of the underlying mechanism showed that MP modulated gut microbial community by 16S rRNA analysis and reversed the elevation of lipid indexes by plasma lipidomics analysis. Correlation analysis indicated that the abundance of seven key bacterial species and six lipids were closely associated with the metabolic traits, respectively. Overall, MP could ameliorate metabolic disorders, and modify the gut microbiota and lipids. This would greatly facilitate the utilization of MP as a functional food.

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Mulberry leaves ameliorate obesity through enhancing brown adipose tissue activity and modulating gut microbiota

Abstract: The increased prevalence of obesity significantly affects human health worldwide.

Cited by 58 publications

References 49 publications

Flavonoids from Mulberry Leaves Alleviate Lipid Dysmetabolism in High Fat Diet-Fed Mice: Involvement of Gut Microbiota

Flavonoids from Mulberry Leaves Alleviate Lipid Dysmetabolism in High Fat Diet-Fed Mice: Involvement of Gut Microbiota

Flavonoids, gut microbiota, and host lipid metabolism

Mulberry (Morus alba L.) leaf polysaccharide ameliorates insulin resistance‐ and adipose deposition‐associated gut microbiota and lipid metabolites in high‐fat diet‐induced obese mice

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