Flavonoids, gut microbiota, and host lipid metabolism

Abstract

Flavonoids are widely distributed in nature and have a variety of beneficial biological effects, including antioxidant, anti‐inflammatory, and anti‐obesity effects. All of these are related to gut microbiota, and flavonoids also serve as a bridge between the host and gut microbiota. Flavonoids are commonly used to modify the composition of the gut microbiota by promoting or inhibiting specific microbial species within the gut, as well as modifying their metabolites. In turn, the gut microbiota extensively metabolizes flavonoids. Hence, this reciprocal relationship between flavonoids and the gut microbiota may play a crucial role in maintaining the balance and functionality of the metabolism system. In this review, we mainly highlighted the biological effects of antioxidant, anti‐inflammatory and antiobesity, and discussed the interaction between flavonoids, gut microbiota and lipid metabolism, and elaborated the potential mechanisms on host lipid metabolism.

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“…Thus, cocoa bean husk extract has been shown to have antibacterial and antiglucosyltransferase activities (Prince et al, 2022). Flavonoids are a large class of heterocyclic organic compounds produced by the secondary metabolism of natural plants (Suripta et al, 2023), Widely found in fruits, vegetables and nuts in the form of flavonoid glycosides (Mueed et al, 2023), They play important probiotic effects on antioxidant, antibacterial and antiinflammatory, antitumor, immune regulation, and gut health (Zhou et al, 2023).…”