Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues

Quantitatively characterizing the microstructural features of breast ductal carcinoma tissues in different progression stages by Mueller matrix microscope

“…Equation (3) defines two MMT parameters used in this study. Both the experimental and simulation results have shown that the MMPD parameter δ and MMT parameter t are closely related to the density of the fibrous structures, while the MMPD parameter θ and MMT parameter x represent the orientation direction of the fibrous structures in tissue slices [16,21,25,36]. The values of the parameters δ and t and the distribution behavior of the parameters θ and x may be used to indicate the density and orientation of the fibrous structures in breast duct tissue sections.…”

“…The values of the parameters δ and t and the distribution behavior of the parameters θ and x may be used to indicate the density and orientation of the fibrous structures in breast duct tissue sections. Although the MMPD and MMT parameters can both be used for the detections of fibers, they have different advantages: our previous study have shown that the MMPD parameters are slightly more sensitive to the fibers, whereas the MMT parameters are easier and quicker to compute [25].…”

“…The previous literature shows that more than 85% of cancers originate from the superficial epithelium, which means that polarization imaging methods have great potential in screening and identifying cancer at an early stage [19,20]. Therefore, Mueller matrix polarimetry has been used to assist the diagnosis of various cancerous tissues, such as skin cancer [21], cervical cancer [22], colon cancer [23], liver cancer [24,25], and so on [26,27]. Recently, we have designed a Mueller matrix microscope by adding a polarization state generator and analyzer (PSG and PSA) to a commercial transmission-light microscope and applied it to detect human liver and cervical cancerous tissues with fibrosis [24,25].…”

“…Therefore, Mueller matrix polarimetry has been used to assist the diagnosis of various cancerous tissues, such as skin cancer [21], cervical cancer [22], colon cancer [23], liver cancer [24,25], and so on [26,27]. Recently, we have designed a Mueller matrix microscope by adding a polarization state generator and analyzer (PSG and PSA) to a commercial transmission-light microscope and applied it to detect human liver and cervical cancerous tissues with fibrosis [24,25]. With the advantages of simple structure, fast imaging speed and low cost, the Mueller matrix microscope shows good prospects for the detection of fibrous structures.…”

Modulus design multiwavelength polarization microscope for transmission Mueller matrix imaging

“…1,2 They have been applied in different fields, including material characterization, 3,4 medical diagnosis, 5 remote sensing, 6 target detection, 7 and so on. The observation of microstructure makes it necessary to combine polarization imaging techniques with microscope systems.…”