Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers: Synthesis, structural characterisation and diffusion studies

Ways, Twana Mohammed M.; Filippov, Sergey K.; Maji, Samarendra; Glaßner, Mathias; Cegłowski, Michal; Hoogenboom, Richard; King, Stephen M.; Lau, Wing Man; Khutoryanskiy, Vitaliy V.

doi:10.1016/j.jcis.2022.06.126

Cited by 32 publications

(19 citation statements)

References 67 publications

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“…Even with available literature, it is difficult to conclude the driving factors behind the enhanced propulsion experienced by our coated microparticles. A lot of studies done investigating PEG and chitosan involved nanoparticles 32 , 40 , which are orders of magnitude smaller, and other literature involves experimental studies that cannot be directly related to our work 33 . Based on what we do know, it seems likely that molecular weight is a driving factor in mucin interactions, with electrostatic interactions also having some contributions.…”

Section: Resultsmentioning

confidence: 99%

“…It is difficult to conclude an exact relationship between chemical coatings and improved propulsion behavior; we speculate from literature that these interactions are the result of molecular weight and electrostatic force differences between different coatings. In addition, we believe that unexplored physiochemical interactions between active microparticles and mucin glycoproteins are heavily contributing to these results and make it difficult for effective comparisons with studies involving passive nanoparticles 32 , 40 .…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles

Rogowski

Kim

2022

Sci Rep

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Chemically coated micro/nanoparticles are often used in medicine to enhance drug delivery and increase drug up-take into specific areas of the body. Using a recently discovered spontaneous symmetry breaking propulsion mechanism, we demonstrate that chemically coated microparticles can swim through mucus solution under precise navigation and that certain functionalizations can dynamically change propulsion behavior. For this investigation biotin, Bitotin-PEG3-amine, and biotin chitosan were chemically functionalized onto the surfaces of magnetic microparticles using an avidin–biotin complex. These chemicals were chosen because they are used prolifically in drug delivery applications, with PEG and chitosan having well known mucoadhesive effects. Coated microparticles were then suspended in mucus synthesized from porcine stomach mucins and propelled using rotating magnetic fields. The relationship between different chemical coatings, microparticle velocity, and controllability were thoroughly explored and discussed. Results indicate that the biotinylated surface coatings altered the propulsion behavior of microparticles, with performance differences interlinked to both magnetic field properties and localized mucus properties. Precisely controlled drug carrying microparticles are envisioned to help supplant traditional drug delivery methods and enhance existing medical techniques utilizing micro/nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles

Rogowski

Kim

2022

Sci Rep

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“…As a solution, antiadhesive nanoparticles weakly interact with the mucus layer: although this property increases the quantity of nanoparticles lost in the digestive and respiratory systems post-administration, it increases nanoparticle diffusion rate across mucus. For this reason, antiadhesive nanoparticles have also been proposed for IN drug delivery [ 47 , 48 , 49 , 50 ].…”

Section: Biomaterials-based Vehicles For In Drug Deliverymentioning

confidence: 99%

“…Ways et al investigated the possibility to create mucus-inert chitosan nanoparticles through grafting with PEG, PHEA, POZ and PVP. All the modified nanocarriers showed superior mucus penetration compared to unmodified chitosan with PVP showing the highest penetration depth in ex vivo sheep nasal mucosa [ 48 ].…”

Section: Biomaterials-based Vehicles For In Drug Deliverymentioning

confidence: 99%

Biomaterials-Enhanced Intranasal Delivery of Drugs as a Direct Route for Brain Targeting

Marcello

Chiono

2023

IJMS

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Intranasal (IN) drug delivery is a non-invasive and effective route for the administration of drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain barrier (BBB) and minimizing adverse side effects. IN drug delivery can be particularly promising for the treatment of neurodegenerative diseases. The drug delivery mechanism involves the initial drug penetration through the nasal epithelial barrier, followed by drug diffusion in the perivascular or perineural spaces along the olfactory or trigeminal nerves, and final extracellular diffusion throughout the brain. A part of the drug may be lost by drainage through the lymphatic system, while a part may even enter the systemic circulation and reach the brain by crossing the BBB. Alternatively, drugs can be directly transported to the brain by axons of the olfactory nerve. To improve the effectiveness of drug delivery to the brain by the IN route, various types of nanocarriers and hydrogels and their combinations have been proposed. This review paper analyzes the main biomaterials-based strategies to enhance IN drug delivery to the brain, outlining unsolved challenges and proposing ways to address them.

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“…Many research studies concentrate on composite materials, including chitosan and other components such as biological species [ 85 , 86 ], metals [ 87 , 88 , 89 ], synthetic polymers [ 90 , 91 , 92 ], and others. A foam complex between negatively charged DNA and cationic chitosan was studied as a functional material for drug delivery [ 93 ].…”

Section: Chitosanmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

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Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers: Synthesis, structural characterisation and diffusion studies

Cited by 32 publications

References 67 publications

Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles

Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles

Biomaterials-Enhanced Intranasal Delivery of Drugs as a Direct Route for Brain Targeting

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

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