Mucuna sanjappae Aitawade et Yadav: a new species of Mucuna with promising yield of anti-Parkinson’s drug L-DOPA

Patil, Ravishankar; Gholave, Avinash R.; Jadhav, Jyoti P.; Yadav, Shrirang R.; Bapat, Vishwas A.

doi:10.1007/s10722-014-0164-8

Cited by 19 publications

(9 citation statements)

References 30 publications

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“…Anti-Parkinson’s activities of flavonoids have been also reported on 6-OHDA-induced experimental Parkinsonism in vivo and in vitro ( Mu et al, 2009 ). Phenolics and flavonoids are important class of natural antioxidant substances having potential of scavenging free radicals, ultimately reducing the risk of oxidative stress related disorders including cancer and PD ( Saxena et al, 2012 ; Patil et al, 2015 ). Recently, Cilia et al (2017) have reported that 12.5–17.5 mg/kg Mp seed powder shows neuroprotective activity in PD patient with a more favorable tolerability profile.…”

Section: Discussionmentioning

confidence: 99%

Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways

Nand

Birla

Singh

et al. 2017

Front. Aging Neurosci.

121

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Till date, drugs that have been used to manage Parkinson’s disease (PD) have only shown symptomatic relief with several adverse effects besides their inability to prevent neurodegeneration. Neuroinflammation plays an important role in the advancement of PD and can be targeted for its effective treatment. Researchers have suggested that herbal plants exhibiting the anti-inflammatory and anti-oxidant properties are therefore beneficial to human health. Conventionally, Mucuna pruriens (Mp) seeds are used for maintaining male virility in India. Reportedly, Mp is used as a rejuvenator drug having neuroprotective property. Our study aimed to investigate effects of aqueous extract of Mp (100 mg/kgbwt) on neuroinflammation, orally administered to mice intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as well as the molecular mechanism involved in the progression of PD. In this study, we have observed significant behavioral abnormalities beside decreased antioxidant defense in MPTP intoxicated mice. We have also observed significant increase in inflammatory parameters like Glial Fibrillary Acidic Protein, Inducible Nitric Oxide Synthase, Intercellular Cell Adhesion Molecule, and Tumor Necrosis Factor alpha in substantia nigra pars compacta (SNpc) of parkinsonian mice, while Mp treatment has notably reduced these inflammatory parameters. Mp also inhibited the MPTP induced activation of NF-κB and promoted pAkt1 activity which further prevented the apoptosis of the dopaminergic neurons. Moreover, Mp exhibited significant antioxidant defense by inhibiting the lipid peroxidation and nitrite level, and by improving catalase activity and enhancing GSH level in nigrostriatal region of mouse brain. Mp also recovered the behavioral abnormalities in MPTP treated mice. Additionally, Mp treatment considerably increased the immunoreactivity of Tyrosine Hydroxylase and Dopamine Transporter in SNpc of parkinsonian mice. Our high performance liquid chromatography analysis of the Mp seed extract have shown L-DOPA, gallic acid, phytic acid, quercetin, and catechin equivalents as the major components which might cause neuroprotection in PD mice. Our result suggested that Mp extract treatment containing L-DOPA and a mixture of rich novel phytochemicals significantly alleviates the MPTP induced neurotoxicity by NF-κB and pAkt pathway. The findings observed thereby indicate that Mp extract have suggestively ameliorated MPTP induced neuroinflammation, restored the biochemical and behavioral abnormalities in PD mouse and thus provided a scientific basis for its traditional claim.

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Section: Discussionmentioning

confidence: 99%

Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways

Nand

Birla

Singh

et al. 2017

Front. Aging Neurosci.

121

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“…The seeds of the Mucuna plant, also affectionately known as dopa bean, are well known for containing l -Dopa, the go-to drug for treating PD. Although some species of Mucuna contain more l -Dopa than others, the Mucuna plant is generally favoured for the exploitation of l -Dopa due to its relative abundance of which compared to other plant families that have been studied (Patil et al 2015 ). Other microbial and chemical means of synthesizing l -Dopa have also been explored (Surwase et al 2012 ; Krishnaveni et al 2009 ; Ali et al 2007 ; Sikander and Ikram ul 2006 ), but the Mucuna plant has been preferred as it is a natural and inexpensive source, and it provides additional benefits as an antioxidant (Manyam et al 2004 ).…”

Section: Nutraceuticals and Pdmentioning

confidence: 99%

“…Nonetheless, there are also several reports supporting a neuroprotective role of AMPK in PD. In a recent study by Patil et al, MPTP-treated mice on chronic metformin regimen demonstrated enhanced antioxidant activity and brain-derived neurotrophic factor (BDNF) levels, thereby rendering protection against dopaminergic neuronal loss induced by MPP+ (Patil et al 2015 ). In a related study, AMPK is activated upon MPTP treatment, and when AMPK activity is downregulated by compound C, neurotoxicity is enhanced (Choi et al 2010 ).…”

Section: Ampk Activation and Neuroprotectionmentioning

confidence: 99%

Nutraceuticals in Parkinson’s Disease

2016

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Current pharmacological strategies for Parkinson’s disease (PD), the most common neurological movement disorder worldwide, are predominantly symptom relieving and are often plagued with undesirable side effects after prolonged treatment. Despite this, they remain as the mainstay treatment for PD due to the lack of better alternatives. Nutraceuticals are compounds derived from natural food sources that have certain therapeutic value and the advent of which has opened doors to the use of alternative strategies to tackle neurodegenerative diseases such as PD. Notably, nutraceuticals are able to position themselves as a “safer” strategy due to the fact that they are naturally derived compounds, therefore possibly having less side effects. Significant efforts have been put into better comprehending the role of nutraceuticals in PD, and we will look at some of them in this review. Broadly speaking, these compounds execute their positive effects via modulating signalling pathways, inhibiting oxidative stress, inflammation and apoptosis, as well as regulating mitochondrial homoeostasis. Importantly, we will highlight how a component of green tea, epigallocatechin-3-gallate (EGCG), confers neuroprotection in PD via its ability to activate AMP kinase and articulate how its beneficial effects in PD are possibly due to enhancing mitochondrial quality control.

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“…The plants of Mucuna thrive well in dry farming and low soil fertility conditions and exhibit resistance against wide ranging diseases (Buckles 1995;Jorge et al 2007;Siddhuraju et al 2000). Various species of Mucuna are reported with many versatile medicinal and agronomic applications to humankind (Patil et al 2015). Mucuna pruriens (Velvet bean), one of the most studied members of Mucuna, exhibits good agronomic potentials.…”

Section: Introductionmentioning

confidence: 99%

Assessment of genetic diversity in Mucuna species of India using randomly amplified polymorphic DNA and inter simple sequence repeat markers

Patil

Pawar

Rane

et al. 2016

Physiol Mol Biol Plants

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Genus Mucuna which is native to China and Eastern India comprises of perennial climbing legume with long slender branches, trifoliate leaves and bear green or brown pod covered with soft or rigid hairs that cause intense irritation. The plants of this genus are agronomically and economically important and commercially cultivated in India, China and other regions of the world. The high degrees of taxonomical confusions exist in Mucuna species that make authentic identification and classification difficult. In the present study, the genetic diversity among the 59 accessions of six species and three varieties of M. pruriens has been assessed using DNA fingerprinting based molecular markers techniques namely randomly amplified polymorphic DNA (RAPD), inter simple sequence repeats (ISSR) and combined dataset of RAPD and ISSR. Also, genetic relationship among two endemic species of Mucuna namely M. imbricata and M. macrocarpa and two varieties namely IIHR hybrid (MHR) and Dhanwantari (MD) with other species under study was investigated by using cluster analysis and principal coordinate analysis.The cluster analysis of RAPD, ISSR and combined dataset of RAPD and ISSR clearly demonstrated the existence of high interspecific variation than intra-specific variation in genus Mucuna. The utility and efficacy of RAPD and ISSR for the study of intra species and interspecies genetic diversity was evident from AMOVA and PCoA analysis. This study demonstrates the genetic diversity in Mucuna species and indicates that these markers could be successfully used to assess genetic variation among the accessions of Mucuna species.

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Mucuna sanjappae Aitawade et Yadav: a new species of Mucuna with promising yield of anti-Parkinson’s drug L-DOPA

Cited by 19 publications

References 30 publications

Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways

Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways

Nutraceuticals in Parkinson’s Disease

Assessment of genetic diversity in Mucuna species of India using randomly amplified polymorphic DNA and inter simple sequence repeat markers

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