Mucosal irritation potential of polyelectrolyte multilayer capsules

Polymeric multilayer capsules delivering biotherapeutics

“…However, several studies have pointed out that both planar films as well as capsules consisting of polyelectrolyte complexes do not exhibit significant toxicity. [7,100,101] Therefore, a thorough debate should be performed in order to assess in which conditions polycation related toxicity might be an issue or not. On the other hand, there are several research groups switching from the use of electrostatic interactions to the use of hydrogen bonding as driving for multilayer assembly, thus avoiding the use of polycations.…”

Design and characterization of microcapsules-integrated collagen matrixes as multifunctional three-dimensional scaffolds for soft tissue engineering

“…This result is in agreement with previous data reported from , who observed that to render the capsule surface cationic, an additional PARG layer had to be deposited after the core removal step with EDTA. This phenomenon had been attributed to a rearrangement of the excess of anionic compounds released upon dissolution of the CaCO 3 templates and redistributed through the capsule membrane (De Cock et al, 2011). Accordingly, the deposition of an additional PARG layer reversed the zeta potential to a cationic value (10.775.0 mV) (Fig.…”

Nanoporous polyelectrolyte vaccine microcarriers. A formulation platform for enhancing humoral and cellular immune responses

“…This is in accordance with the recent observations by our research group on the effect of complexation on the in vivo mucosal irritation potential of polyelectrolytes. Indeed, whereas soluble polyelectrolytes, both polyanions and even more severely polycations, do induce mucosal irritation, this was fully suppressed in the case of polyelectrolyte complexes [30].…”