Mucosal involvement in systemic and chronic cutaneous lupus erythematosus

Burge, Susan; Frith, Peggy; Juniper, R.P.; Wojnarowska, Fenella

doi:10.1111/j.1365-2133.1989.tb08215.x

Cited by 156 publications

(98 citation statements)

References 20 publications

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“…223 Immunoreactant deposi tion at the BMZ from conjunctival lesions in SLE patients was usually granular ? 1 , 22 However, linear depositions of immunoreactants similar to those found in OCP were detected in 5 of 12 SLE patients with clinically uninvolved conjunctiva by Burge et al 16 and in 4 of our patients with actively inflamed conjunctiva.…”

Section: Discussionmentioning

confidence: 85%

Histology and immunopathology of systemic lupus erythematosus affecting the conjunctiva

Heiligenhaus

Dutt

Foster

1996

Eye

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Section: Discussionmentioning

confidence: 85%

Histology and immunopathology of systemic lupus erythematosus affecting the conjunctiva

Heiligenhaus

Dutt

Foster

1996

Eye

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“…Present study recorded 16 patients (17.02%) of Systemic Lupus Erythematosus, comprising 13 females and 3 males. Burge [4] in their study of 53 patients with SLE found 48 females and 5 males. Most of the lesions confined to Palate (87.5%) in our study, whereas SM Burge (1989) reported that lips and palate are the commonest site of involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Lips were the commonest site involved. Burge SM (1989) found 42 females and 26 males in their study group of 68 patients with DLE. Buccal mucosa was the commonest site affected.…”

Section: Discussionmentioning

confidence: 99%

Oral Dermatological Conditions: A Clinical Study

Roy

Varshney

2012

Indian J Otolaryngol Head Neck Surg

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Oral cavity consists of a small vestibule and a larger oral cavity proper. A wide number of dermatological conditions can affect the oral cavity. The clinical characteristics of the same were studied in patients attending departments of Dermatology/ENT Himalayan Institute of Medical Sciences, Dehradun. To delineate and identify the various patterns of oral dermatological conditions in this part of the country. One hundred and fifty patients were included in the study having oral lesions irrespective of age, sex and duration. Clinical examination including cutaneous examination and simple investigations like routine blood, urine, stool, blood sugar, KOH mount and scraping, Tzanck test, and on certain cases biopsy were carried out. Out of 11,840 patients attending Dermatology/ENT OPD, HIMS, Dehradun from April 2008 to March 2009, 150 patients were having various disorders with oral manifestations. The incidence of oral cavity dermatoses in this study was 1.26%, male to female ratio was 2:3. (Out of 150 patients, 60 were males and 90 were females). Aphthous ulcer (28.57%) and pemphigus vulgaris (26.60%) formed the major bulk of patients followed by SLE (17.02%), oral candidiasis (16.07%), DLE (13.83%), lichen planus (12.77%) and others.

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“…Ocular rosacea 3,137 Some scarring is common Dermatitis herpetiformis 128 Rarely causes scarring Lichen planus 138,139 Rarely causes scarring Systemic lupus and discoid lupus 140 Rarely causes scarring…”

Section: Dermal Diseases With Variable Ocular Involvementmentioning

confidence: 99%

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

Dart

2017

Eye

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This review is in two sections. The first section summarises 35 conditions, both common and infrequent, causing cicatrising conjunctivitis. Guidelines for making a diagnosis are given together with the use of diagnostic tests, including direct and indirect immunofluorescence, and their interpretation. The second section evaluates our knowledge of ocular mucous membrane pemphigoid, which is the commonest cause of cicatrizing conjunctivitis in most developed countries. The clinical characteristics, demographics, and clinical signs of the disease are described. This is followed by a review and re-evaluation of the pathogenesis of conjunctival inflammation in mucous membrane pemphigoid (MMP), resulting in a revised hypothesis of the autoimmune mechanisms causing inflammation in ocular MMP. The relationship between inflammation and scarring in MMP conjunctiva is described. Recent research, describing the role of aldehyde dehydrogenase (ALDH) and retinoic acid (RA) in both the initiation and perpetuation of profibrotic activity in MMP conjunctival fibroblasts is summarised and the potential for antifibrotic therapy, using ALDH inhibition, is discussed. The importance of the management of the ocular surface in MMP is briefly summarised. This is followed with the rationale for the use of systemic immunomodulatory therapy, currently the standard of care for patients with active ocular MMP. The evidence for the use of these drugs is summarised and guidelines given for their use. Finally, the areas for research and innovation in the next decade are reviewed including the need for better diagnostics, markers of disease activity, and the potential for biological and topical therapies for both inflammation and scarring.

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Mucosal involvement in systemic and chronic cutaneous lupus erythematosus

Cited by 156 publications

References 20 publications

Histology and immunopathology of systemic lupus erythematosus affecting the conjunctiva

Histology and immunopathology of systemic lupus erythematosus affecting the conjunctiva

Oral Dermatological Conditions: A Clinical Study

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

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